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A detailed way to establish correlations between ionic currents in PD neurons of the crab Stomatogastric ganglion
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Yu, Li. A detailed way to establish correlations between ionic currents in PD neurons of the crab Stomatogastric ganglion. Retrieved from https://doi.org/doi:10.7282/T3GX496P

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TitleA detailed way to establish correlations between ionic currents in PD neurons of the crab Stomatogastric ganglion
NameYu, Li (author); Golowasch, Jorge (chair); Nadim, Farzan (internal member); Rutgers University; Graduate School - Newark
Date Created2013
Other Date2013-05 (degree)
SubjectBiology, Ganglia, Sensory, Cancer (Crustacea)
Extentvii, 33 p. : ill.
DescriptionTwo electrically-coupled PD neurons in the stomatogastric ganglion (STG) of the crab, Cancer borealis are coupled with the pacemaker AB neuron. In recent years, several research groups have reported that a number of currents seem to be coexpressed in PD neurons, as revealed by a correlation in the amplitude of the currents, conductances or mRNA that codes for them. Among these currents, the correlations between the transient potassium outward current (IA), the high-threshold potassium outward current (IHTK) and the hyperpolarization-activated inward current (IH) are well established. Research also found that some of the currents may be coregulated constitutively, such as IA-IH, and some may be dependent on neuromodulators, such as IA-IHTK, and IHTK-IH. The study presented here uses a more detailed and different way to measure the maximal conductance of IA, IHTK, IH, with the goal of determining if current parameters other than the maximal conductance may be correlated. Here I also analyze possible relationships of the two known components of IHTK: the calcium-dependent potassium current (IKCa) and the delayed rectifier current (IKd). The results I have observed are consistent with the previous studies and confirm significant positive linear correlations between IA and IHTK, IA and IH, and IHTK and IH. Even though the sample number is limited, I have also established the correlation between the two components of IHTK: IKCa and IKd, which is a result that contrasts with those at the mRNA level in which no significant linear correlations between BK-KCa (a gene that encodes for IKCa) and shab (a gene that encodes for IKd), and BK-KCa and shaw (a gene also encodes for IKd) were found. The other new finding here is the correlation in maximal conductance between IKCa and IH, and IKd and IH, which is consistent with the correlation of BK-KCa and H (a gene that encodes for IH), and contrasts with the lack of significant correlations of shab and H, shaw and H.
NoteM.S.
NoteIncludes bibliographical references
Noteby Li Yu
Genretheses, ETD graduate
Persistent URLhttps://doi.org/doi:10.7282/T3GX496P
Languageeng
CollectionGraduate School - Newark Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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