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A detailed way to establish correlations between ionic currents in PD neurons of the crab Stomatogastric ganglion

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Title
A detailed way to establish correlations between ionic currents in PD neurons of the crab Stomatogastric ganglion
Name (type = personal)
NamePart (type = family)
Yu
NamePart (type = given)
Li
NamePart (type = date)
1988-
DisplayForm
LI YU
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Golowasch
NamePart (type = given)
Jorge
DisplayForm
Jorge Golowasch
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Nadim
NamePart (type = given)
Farzan
DisplayForm
Farzan Nadim
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - Newark
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2013
DateOther (qualifier = exact); (type = degree)
2013-05
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Two electrically-coupled PD neurons in the stomatogastric ganglion (STG) of the crab, Cancer borealis are coupled with the pacemaker AB neuron. In recent years, several research groups have reported that a number of currents seem to be coexpressed in PD neurons, as revealed by a correlation in the amplitude of the currents, conductances or mRNA that codes for them. Among these currents, the correlations between the transient potassium outward current (IA), the high-threshold potassium outward current (IHTK) and the hyperpolarization-activated inward current (IH) are well established. Research also found that some of the currents may be coregulated constitutively, such as IA-IH, and some may be dependent on neuromodulators, such as IA-IHTK, and IHTK-IH. The study presented here uses a more detailed and different way to measure the maximal conductance of IA, IHTK, IH, with the goal of determining if current parameters other than the maximal conductance may be correlated. Here I also analyze possible relationships of the two known components of IHTK: the calcium-dependent potassium current (IKCa) and the delayed rectifier current (IKd). The results I have observed are consistent with the previous studies and confirm significant positive linear correlations between IA and IHTK, IA and IH, and IHTK and IH. Even though the sample number is limited, I have also established the correlation between the two components of IHTK: IKCa and IKd, which is a result that contrasts with those at the mRNA level in which no significant linear correlations between BK-KCa (a gene that encodes for IKCa) and shab (a gene that encodes for IKd), and BK-KCa and shaw (a gene also encodes for IKd) were found. The other new finding here is the correlation in maximal conductance between IKCa and IH, and IKd and IH, which is consistent with the correlation of BK-KCa and H (a gene that encodes for IH), and contrasts with the lack of significant correlations of shab and H, shaw and H.
Subject (authority = RUETD)
Topic
Biology
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_4772
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
vii, 33 p. : ill.
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Li Yu
Subject (authority = ETD-LCSH)
Topic
Ganglia, Sensory
Subject (authority = ETD-LCSH)
Topic
Cancer (Crustacea)
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10002600001.ETD.000068790
RelatedItem (type = host)
TitleInfo
Title
Graduate School - Newark Electronic Theses and Dissertations
Identifier (type = local)
rucore10002600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3GX496P
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
YU
GivenName
LI
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2013-04-30 12:50:52
AssociatedEntity
Name
LI YU
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - Newark
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Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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