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A research summary 1) RNA binding proteins, 2) Selective constraint on copy number variation in human PIWI-interacting RNA loci
Descriptive
TitleInfo
Title
A research summary 1) RNA binding proteins, 2) Selective constraint on copy number variation in human PIWI-interacting RNA loci
TitleInfo
(type = abbreviated)
Title
RNA binding proteins
TitleInfo
(type = abbreviated)
Title
Selective constraint on copy number variation in human PIWI-interacting RNA loci
Name
(type = personal)
NamePart
(type = family)
Gould
NamePart
(type = given)
David William
NamePart
(type = date)
1986-
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David Gould
Role
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author
Name
(type = personal)
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(type = family)
Chen
NamePart
(type = given)
Kevin
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Kevin Chen
Affiliation
Advisory Committee
Role
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chair
Name
(type = personal)
NamePart
(type = family)
Sontag
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(type = given)
Eduardo
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Eduardo Sontag
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Advisory Committee
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internal member
Name
(type = personal)
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(type = family)
Schliep
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(type = given)
Alexander
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Alexander Schliep
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Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
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(type = family)
Buyske
NamePart
(type = given)
Steve
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Steve Buyske
Affiliation
Advisory Committee
Role
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outside member
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Rutgers University
Role
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(authority = RULIB)
degree grantor
Name
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Graduate School - New Brunswick
Role
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school
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Text
Genre
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theses
OriginInfo
DateCreated
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2013
DateOther
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(type = degree)
2013-05
Place
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xx
Language
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(type = code)
eng
Abstract
The overall aim of my research dealt with the understanding of regulatory elements in various systems (most important, in humans) through two research projects 1) a study of RNA Binding Proteins in S. cerevisiae and 2) a study of piRNA in humans. My first project involved the study of RNA Binding Proteins – thought to play a role in post-transcriptional translation in mammals. The algorithms miReduce and PhyloGibbs were used towards the prediction of binding sites for these proteins in S. cerevisiae. The putative binding sites found with the algorithms miReduce and PhyloGibbs warrant more extensive analysis, but further work needs to be done to determine the importance of secondary structure conservation inherent in many functional RNAs. The second project examined the nature of piwi-interacting RNA (piRNA). piRNA are small noncoding RNA that are found in animals thought to act as regulatory elements in the germ-line. This study in particular considers possible forces of selection on piRNA through the analysis of their copy number variation in humans. Three human populations were included in the data used: Europeans, Yorubans, and Chinese/Japanese. Results from our methods support a hypothesis of negative selection on piRNA; they were presented in a publication co-authored by Dr. Kevin Chen and myself [11].
Subject
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Topic
Computational Biology and Molecular Biophysics
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Title
Rutgers University Electronic Theses and Dissertations
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ETD_4625
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electronic resource
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application/pdf
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text/xml
Extent
v, 24 p. : ill.
Note
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M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = vita)
Includes vita
Note
(type = statement of responsibility)
by David William Gould
Subject
(authority = ETD-LCSH)
Topic
RNA-protein interactions
Subject
(authority = ETD-LCSH)
Topic
Genetic regulation
Identifier
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http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000068863
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Title
Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T370801R
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
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The author owns the copyright to this work.
RightsHolder
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Name
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Gould
GivenName
David
Role
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Permission or license
DateTime
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2013-04-10 21:29:11
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Name
David Gould
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Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
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windows xp
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