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Changing fate
Descriptive
TitleInfo
Title
Changing fate
SubTitle
cellular reprogramming
Name
(type = personal)
NamePart
(type = family)
Guarino
NamePart
(type = given)
Alyx
DisplayForm
Alyx Guarino
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Mckinnon
NamePart
(type = given)
Randall
DisplayForm
Randall Mckinnon
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Matise
NamePart
(type = given)
Michael
DisplayForm
Michael Matise
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Yurchenco
NamePart
(type = given)
Peter
DisplayForm
Peter Yurchenco
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
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NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
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school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2013
DateOther
(qualifier = exact);
(type = degree)
2013-05
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Tissue and organ transplantations have historically been limited to allogenic donor grafts. Allografts can restore some degree of functionality to the transplant site, but they are a less-than-optimal substitute for patient-derived materials, as they require patient immunosuppression. The ideal clinical approach is to replace damaged tissue and organs with grafts grown directly from cells harvested from the patient. The induction of pluripotency in fibroblasts was one of the first experiments to show that cell fate could be reprogrammed, to a pluripotent state, by overexpressing four transcription factors – Oct4, Sox2, Klf4, and Nanog. Later research by other groups discovered that cells could also be directly reprogrammed into other cell types, without going through a pluripotent intermediate step. Direct cell reprogramming presents a method to generate a source of patient-specific graft tissues and organs. In this thesis, I aim to provide a molecular mechanistic model for direct cell reprogramming. Evidence suggests a model in which pioneer molecules make a cell competent for reprogramming by gaining a foothold at key promoter sites, thereby making the binding site accessible to epigenetic modification by chromatin remodeling complexes.
Subject
(authority = RUETD)
Topic
Cell and Developmental Biology
Subject
(authority = ETD-LCSH)
Topic
Cell determination
Subject
(authority = ETD-LCSH)
Topic
Cell differentiation
Subject
(authority = ETD-LCSH)
Topic
Cell proliferation--Molecular aspects
Subject
(authority = ETD-LCSH)
Topic
Cytology--Research
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
Identifier
ETD_4602
PhysicalDescription
Form
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electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
vii, 35 p. : ill.
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Alyx Guarino
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000068868
RelatedItem
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TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Location
PhysicalLocation
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3N878D3
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Guarino
GivenName
Alyx
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2013-04-15 01:56:11
AssociatedEntity
Name
Alyx Guarino
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
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ContentModel
ETD
OperatingSystem
(VERSION = 5.1)
windows xp
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