DescriptionBackground: Cognitive behavioral guided self-help (CBTgsh) is a brief, evidence-based treatment for recurrent binge eating. Little is known, however, about implementation strategies that effectively translate evidence-based treatments into routine clinical care settings. Aims: The present study evaluates the effectiveness and acceptability of CBTgsh for college students seeking treatment at a university counseling center (CAPS) employing the “train-the-trainer” implementation strategy. Method: A doctoral student received expert-led training in CBTgsh and subsequently trained and supervised more junior graduate students to implement the treatment in an open clinical trial. Therapists provided 10 sessions of CBTgsh to 23 treatment-seeking students with bulimia nervosa, binge eating disorder, or eating disorder not otherwise specified. Results: Intent-to-treat analyses revealed 48.7% abstinence from binge eating at post-treatment and 56.5% at one-month follow-up. Participants reported significant pre-to-post treatment reductions on measures of specific eating disorder psychopathology, general psychopathology, and functional impairment. Participants and counseling center staff reported high levels of treatment acceptability. Conclusions: The results of the current study provide “proof-of-concept” for the train-the-trainer method of implementation. Outcomes were comparable to findings from two of the largest randomized controlled trials of CBTgsh conducted to date and suggest that, given adequate training and supervision, specialized therapist credentials are not necessary for successful CBTgsh implementation. These results add to the evidence supporting the acceptability, feasibility, and clinical effectiveness of CBTgsh for eating disorders in non-specialized settings.