DescriptionMeniscal tears increase joint cartilage strains and contribute to the development of osteoarthritis of the knee. Tears within the meniscal body and at the root result in altered load transmission and cartilage damage, elucidating the need for tissue-engineered solutions. The first part of this study aims to examine the effect of meniscal scaffold fabrication techniques on the mechanical properties of poly (DT DDD) fibers. Electrospinning will also be evaluated as a new fabrication technique for partial meniscus replacements, preserving more native tissue than previous tissue-engineered solutions. Finally, the ovine meniscal root will be characterized in order to strengthen large animal model trials. While the human meniscus has been well characterized, little is known about the ovine meniscus, a model commonly used in orthopaedic research. Implants are more likely to fail during pre-clinical testing when their fixation technique does not take the model’s native biomechanics into account. Increased knowledge of scaffold fabrication techniques and the ovine meniscus will allow for better adaptation of tissue-engineered replacements to a large animal model, a crucial step prior to human clinical trials.