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Arc protein expression within discrete subfields of the hippocampus following trace fear conditioning

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TitleInfo
Title
Arc protein expression within discrete subfields of the hippocampus following trace fear conditioning
Name (type = personal)
NamePart (type = family)
Hudgins
NamePart (type = given)
Caleb Deneb
NamePart (type = date)
1982-
DisplayForm
Caleb Hudgins
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Otto
NamePart (type = given)
Timothy
DisplayForm
Timothy Otto
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
West
NamePart (type = given)
Mark
DisplayForm
Mark West
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Matzel
NamePart (type = given)
Louis
DisplayForm
Louis Matzel
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2013
DateOther (qualifier = exact); (type = degree)
2013-10
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
A growing body of evidence suggests not only that the dorsal and ventral subregions of the hippocampus contribute differentially to some forms of memory, but that the contribution of the discrete subfields (CA1, CA3) within the hippocampus may also be dissociable. In the present study, we examined the regional distribution of learning-related Arc (activity-related cytoskeletal protein) expression following training in hippocampal-dependent trace fear conditioning. . We have recently shown that trace fear conditioning enhances Arc protein levels, and that both trace fear conditioning and the associated learning-related enhancement of Arc can be blocked by infusing either Arc antisense oligodeoxynucleotides (ODNs) or the NMDA receptor antagonist APV into the dorsal or ventral hippocampus prior to training. Thus while NMDAr –dependent Arc expression in both dorsal and ventral hippocampus appears to be critically involved in the acquisition of trace fear conditioning, the extent to which Arc is differentially expressed within the discrete subfields of the hippocampus following learning has yet to be characterized. Different groups of subjects were either trained in our auditory trace fear conditioning paradigm, a modified trace fear conditioning paradigm with pre-exposure to the conditioning context, received simple exposure the novel training context, or served as home-cage, handled control subjects. Consistent with our earlier findings, the present results suggest a substantial percent increase in Arc expression in both the dorsal and ventral hippocampus following either trace fear conditioning paradigm. With respect to the regional distribution of Arc, expression was greater in CA3 relative to CA1 in the dorsal hippocampus, whereas expression increased in both CA1 and CA3 in ventral hippocampus compared to home cage controls. Interestingly animals exposed to the novel training context also exhibited increased levels of Arc protein expression in patterns similar to those of animals trained in trace fear conditioning, though to a lesser extent. When considered together with our previous data regarding learning-related Arc expression and the known anatomical connections between the hippocampus and the amygdala, these results further support a dissociable role of NMDA mediated Arc expression, not just along the dorsal-ventral axis, but within the discrete subfields of both hippocampal subregions.
Subject (authority = RUETD)
Topic
Psychology
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_5044
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
iii, 37 p. : ill.
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Caleb Deneb Hudgins
Subject (authority = ETD-LCSH)
Topic
Hippocampus (Brain)--Research
Subject (authority = ETD-LCSH)
Topic
Conditioned response
Subject (authority = ETD-LCSH)
Topic
Fear
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3J38QKF
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Hudgins
GivenName
Caleb
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2013-09-30 16:47:19
AssociatedEntity
Name
Caleb Hudgins
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
Type
Embargo
DateTime (point = end); (encoding = w3cdtf); (qualifier = exact)
2014-10-31
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after October 31st, 2014.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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