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The potential effect of triterpenoids in triple negative breast cancer

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TitleInfo
Title
The potential effect of triterpenoids in triple negative breast cancer
Name (type = personal)
NamePart (type = family)
Lin
NamePart (type = given)
Janice Janing
DisplayForm
Janice Lin
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Suh
NamePart (type = given)
Nanjoo
DisplayForm
Nanjoo Suh
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Cohick
NamePart (type = given)
Wendie
DisplayForm
Wendie Cohick
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Yang
NamePart (type = given)
Chung S.
DisplayForm
Chung S. Yang
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2013
DateOther (qualifier = exact); (type = degree)
2013-10
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Triple negative breast cancer (TNBC) classifies as lacking expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (Her-2). TNBC mainly represents basal-like subtype, which consists 80% of TNBC. TNBC has the poorest prognosis and the current standard therapy is chemotherapy. Triterpenoids have been reported as chemopreventive agents for many cancers, including breast cancer. Since natural triterpenoids such as oleanolic acid and ursolic acid were reported to have weak anti-inflammation and anti-cancer effects, synthetic oleanane triterpenoids have been developed to increase biological activity. One such synthetic oleanane triterpenoid, 2-cyano-3, 12-di oxooleana-1, 9-dien-28-oic acid-Imidazolide (CDDO-Im), is a promising agent with potent anti-proliferation and apoptosis activity against various cancers, but the mechanism of these effects remains unclear. In the first part of the project, CDDO-Im inhibited the cell growth, induced G2/M arrest and apoptosis in triple negative breast cancer SUM159 cells. Western blot analysis showed CDDO-Im down-regulated cyclin D1, up-regulated apoptosis markers, and increased DNA damage checkpoint markers that lead to G2/M arrest. Moreover, CDDO-Im repressed the protein level of CD44, pSTAT3 and pNFκB in a dose dependent manner, suggesting that CD44-STAT3 or NFκB signaling may play an important role for the chemopreventive action of CDDO-Im in triple negative breast cancer. In the second part of the project, CDDO-Im decreased CD44+/CD24- cell population in SUM159 monolayers and CD44+/CD24-/ESA+ cell population, which presents as cancer stem cell (CSC) population, in SUM159 mammospheres. CDDO-Im also reduced the number and size of primary and secondary mammospheres in a dose dependent manner. In conclusion, CDDO-Im inhibited TNBC by inducing the G2/M arrest and apoptosis. CDDO-Im had anti-cancer stem cell effect by decreasing the CSC population. These findings suggest the potential use of CDDO-Im for the chemoprevention of TNBC and warrant further in vivo studies and clinical evaluation.
Subject (authority = RUETD)
Topic
Nutritional Sciences
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_4918
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
ix, 91 p. : ill.
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Janice Janing Lin
Subject (authority = ETD-LCSH)
Topic
Breast--Cancer--Treatment
Subject (authority = ETD-LCSH)
Topic
Breast--Cancer--Research
Subject (authority = ETD-LCSH)
Topic
Breast--Cancer--Chemoprevention
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T30Z71B9
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Lin
GivenName
Janice
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2013-07-19 12:16:28
AssociatedEntity
Name
Janice Lin
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2013-10-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2014-05-02
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after May 2nd, 2014.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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