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Nanomaterial inhalation exposure from nanotechnology-based consumer products
Descriptive
TitleInfo
Title
Nanomaterial inhalation exposure from nanotechnology-based consumer products
Name
(type = personal)
NamePart
(type = family)
Nazarenko
NamePart
(type = given)
Yevgen
NamePart
(type = date)
1981-
DisplayForm
Yevgen Nazarenko
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Mainelis
NamePart
(type = given)
Gediminas
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Gediminas Mainelis
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Strom
NamePart
(type = given)
Peter F.
DisplayForm
Peter F. Strom
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Lioy
NamePart
(type = given)
Paul J.
DisplayForm
Paul J. Lioy
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Lee
NamePart
(type = given)
KiBum
DisplayForm
KiBum Lee
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2013
DateOther
(qualifier = exact);
(type = degree)
2013-10
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Certain kinds of nanomaterials have been shown to cause serious health effects. When various nanomaterials are introduced into consumer products, their use could lead to nanomaterial inhalation exposure with possible health effects. We explored the potential of this exposure for several consumer sprays and cosmetic powders including products marketed as nanotechnology-based and alternative non-nanotechnology-based products. Actual application of real world products was realistically simulated and the inhaled aerosol was measured directly. We described: 1) the nanoparticles and nano-agglomerates in products, to which exposure could occur during application by consumers; 2) the potential for inhalation exposure to nanomaterial-containing particulate matter, generated during product application; and 3) the quantitative nanomaterial inhalation exposure as both inhaled dose and dose deposited in different regions of the human respiratory tract (for the cosmetic powders only). Particles in the products were investigated using transmission electron microscopy (TEM), photon correlation spectroscopy (PCS) and laser diffraction spectroscopy (LDS). We then realistically simulated the use of the products by spraying them in the vicinity of a female mannequin head or applying directly onto its face in the case of cosmetic powders. A Scanning Mobility Particle Sizer (SMPS) and an Aerosol Particle Sizer (APS) were used to measure the “inhaled” aerosol particle size distributions by drawing aerosol through the mannequin’s nostrils. The measurement data for powders were also used in an inhalation exposure model. Nanoparticles were found in both the nanotechnology-based and regular products. We could not, however, determine their engineered status. It was concluded that the highest inhalation exposure to nanomaterials in the investigated consumer products would occur due to inhalation and deposition of nanoparticle agglomerates larger than 100 nm – not individual nanoparticles or nanosized agglomerates. For the cosmetic powders, inhaled particle deposition in the head airways constituted the dominant portion (85-93%) of the total deposited dose overwhelming the deposition in the tracheobronchial and the alveolar regions. Hence, the future toxicology studies of nanotechnology-based consumer products should take into account exposures not only to single nanoparticles, but also to much larger nanoparticle agglomerates and investigate the potential biological effects in all regions of the respiratory tract.
Subject
(authority = RUETD)
Topic
Environmental Sciences
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_4941
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
x, 152 p. : ill.
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = vita)
Includes vita
Note
(type = statement of responsibility)
by Yevgen Nazarenko
Subject
(authority = ETD-LCSH)
Topic
Nanostructured materials--Health aspects
Subject
(authority = ETD-LCSH)
Topic
Nanotechnology--Health aspects
Subject
(authority = ETD-LCSH)
Topic
Gases, Asphyxiating and poisonous--Toxicology
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Location
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(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3T43R4Z
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Nazarenko
GivenName
Yevgen
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2013-08-19 17:30:36
AssociatedEntity
Name
Yevgen Nazarenko
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
(ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem
(VERSION = 5.1)
windows xp
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