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Design, synthesis, and fabrication of biodegradable, bioactive-based polymers for controlled release applications

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TitleInfo
Title
Design, synthesis, and fabrication of biodegradable, bioactive-based polymers for controlled release applications
Name (type = personal)
NamePart (type = family)
Ouimet
NamePart (type = given)
Michelle Aimee
NamePart (type = date)
1987-
DisplayForm
Michelle Ouimet
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Uhrich
NamePart (type = given)
Kathryn E.
DisplayForm
Kathryn E. Uhrich
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Hall
NamePart (type = given)
Gene
DisplayForm
Gene Hall
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Warmuth
NamePart (type = given)
Ralf
DisplayForm
Ralf Warmuth
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Di
NamePart (type = given)
Rong
DisplayForm
Rong Di
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2013
DateOther (qualifier = exact); (type = degree)
2013-10
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Novel, controlled release drug delivery systems have transformed therapeutics used in modern medicine but exhibit limitations for treating various diseases. Biodegradable polymers have been extensively studied to overcome such challenges. Through incorporating therapeutic bioactives into a polymer backbone via hydrolytically degradable bonds, high drug loading, improved delivery, and enhanced bioactive stability can be achieved. Polymers containing a non-steroidal anti-inflammatory drug, salicylic acid, and antioxidant molecules from the hydroxycinnamic acid class were synthesized into bioactive-based poly(anhydride-esters) as controlled release drug delivery systems. Polymer properties have been tuned by changing the bioactive covalently incorporated into the monomer unit, altering the monomer’s molecular structure, adding small molecules to the polymer matrix, and fabricating the polymer into different devices. Salicylic acid-based poly(anhydride-ester) (SAPAE) release profiles were first tuned using small molecule admixtures at varying weight percentages to overcome a lag period (i.e., no drug release) for applications where immediate, constant drug release is desired. SAPAEs were also designed as microparticles, or microspheres, for short-term salicylic acid release. These polymers were prepared using monomers comprised of linear aliphatic or heteroatomic molecules with two salicylic acid units. Microsphere size and morphology was determined and the in vitro drug release profile ascertained. Furthermore, to impart brittle SAPAEs with flexible, soft tissue-like properties, the polymer was blended with poly(vinyl pyrrolidone) to formulate miscible films that, when hydrated, exhibit hydrogel-like properties. The material’s morphology, thermal properties, and in vitro drug release profile were elucidated. In addition to engineering SAPAEs for various applications, hydroxycinnamic acids such as p-coumaric, ferulic, and sinapic, which are potent antioxidants with short half-lives and poor chemical stability, were covalently incorporated into a polymer backbone. The chemical composition of precursors and polymers were confirmed and the polymers’ physicochemical characteristics and drug release profiles ascertained. Moreover, the ferulic acid-containing polymer chemical structure was tuned to alter the physicochemical properties and drug release rates. The design, synthesis, physicochemical characterization, drug release profiles, bioactivity assessments, device fabrication methods, biocompatibility evaluations, and potential applications of various bioactive-containing poly(anhydride-ester) are discussed herein.
Subject (authority = RUETD)
Topic
Chemistry and Chemical Biology
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_4872
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xxiii, 212 p. : ill.
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = vita)
Includes vita
Note (type = statement of responsibility)
by Michelle Aimee Ouimet
Subject (authority = ETD-LCSH)
Topic
Polymeric drug delivery systems
Subject (authority = ETD-LCSH)
Topic
Polymers in medicine
Subject (authority = ETD-LCSH)
Topic
Biopolymers
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3WW7FQK
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Ouimet
GivenName
Michelle
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2013-06-06 10:02:50
AssociatedEntity
Name
Michelle Ouimet
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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