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Particulate flows and heteroaggregation studied by optical imaging and fluorescence spectroscopy
Descriptive
TitleInfo
Title
Particulate flows and heteroaggregation studied by optical imaging and fluorescence spectroscopy
Name
(type = personal)
NamePart
(type = family)
Deshpande
NamePart
(type = given)
Kapil V.
NamePart
(type = date)
1984-
DisplayForm
Kapil Deshpande
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Shapley
NamePart
(type = given)
Nina
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Nina Shapley
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Muzzio
NamePart
(type = given)
Fernando
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Fernando Muzzio
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Tomassone
NamePart
(type = given)
Maria
DisplayForm
Maria Tomassone
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Ludescher
NamePart
(type = given)
Richard
DisplayForm
Richard Ludescher
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2014
DateOther
(qualifier = exact);
(type = degree)
2014-01
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
The production of multiscale heteroaggregates of microparticles coated with nanoparticles has generated renewed interest in recent literature due to the wide-ranging applications of such structured particles. These applications include particle stabilization, nanotemplating, and drug delivery, among others. In the past, the majority of heteroaggregation studies and associated applications have involved rigid, spherical particles. However, as part of a multiscale heteroaggregate, hydrophilic hydrogel particles can be used to open a whole range of new applications. These hydrogel particles have also been of great interest recently due to their significant microencapsulation capabilities and variety of delivery mechanisms. This dissertation is focused on gaining understanding of the heteroaggregation of hydrogel microparticles and nanoparticles and of particulate flows that could potentially be used to influence aggregate formation. First, concentrated noncolloidal particle suspensions undergoing oscillatory torsional flow between parallel plates were studied using optical imaging. Much of the work focuses on the effect of moderate strain amplitude and frequency on particle migration. Also explored were various effects that can lead to enhanced or reduced particle migration in the flow. Next, a new quantitative application of fluorescence spectroscopy was developed in order to study the interaction of oppositely charged hydrogel microparticles and nanoparticles in suspensions. Optical microscopy was first used to determine the type of aggregate morphology formed by mixtures of alginate microparticles and fluorescently tagged chitosan nanoparticles at different concentration levels. It was hypothesized that due to fluorophore and particle interaction properties that fluorescence spectroscopy would be able to quantify the boundaries between different types of interactions in the system. With this new technique, the effect of the concentration ratio of nanoparticles to microparticles and the total overall particle concentration was also explored. Finally, after developing the application of fluorescence spectroscopy for quantifying particle interaction, varying the pH of the interaction environment where heteroaggregation occurs was studied. pH is an important parameter in hydrogel microcapsule and nanocapsule delivery and in heteroaggregation behavior. The change in interaction behavior of alginate and chitosan particles was explored and the capabilities and limits of fluorescence spectroscopy were determined.
Subject
(authority = RUETD)
Topic
Chemical and Biochemical Engineering
Subject
(authority = ETD-LCSH)
Topic
Suspensions (Chemistry)
Subject
(authority = ETD-LCSH)
Topic
Rheology
Subject
(authority = ETD-LCSH)
Topic
Fluorescence spectroscopy
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Identifier
ETD_5200
Identifier
(type = doi)
doi:10.7282/T38G8HTD
PhysicalDescription
Form
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electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xvi, 142 p. : ill.
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Kapil V. Deshpande
Location
PhysicalLocation
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Deshpande
GivenName
Kapil
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(qualifier = exact);
(point = start)
2013-12-11 15:32:14
AssociatedEntity
Name
Kapil Deshpande
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
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ContentModel
ETD
OperatingSystem
(VERSION = 5.1)
windows xp
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