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Accumulation and metabolism of neutral lipids in obesity

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TitleInfo
Title
Accumulation and metabolism of neutral lipids in obesity
Name (type = personal)
NamePart (type = family)
Douglass
NamePart (type = given)
John David
NamePart (type = date)
1981-
DisplayForm
John Douglass
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Storch
NamePart (type = given)
Judith
DisplayForm
Judith Storch
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Watford
NamePart (type = given)
Malcolm
DisplayForm
Malcolm Watford
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Brasaemle
NamePart (type = given)
Dawn
DisplayForm
Dawn Brasaemle
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Henderson
NamePart (type = given)
Gregory
DisplayForm
Gregory Henderson
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Connelly
NamePart (type = given)
Margery
DisplayForm
Margery Connelly
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2014
DateOther (qualifier = exact); (type = degree)
2014-01
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
The ectopic deposition of fat in liver and muscle during obesity is well established, however surprisingly little is known about the intestine. We used ob/ob mice and wild type (C57BL6/J) mice fed a high-fat diet (HFD) for 3 weeks, to examine the effects on intestinal mucosal triacylglycerol (TG) accumulation and secretion. Obesity and high-fat feeding resulted in higher levels of mucosal TG and markedly decreased rates of chylomicron secretion, accompanied by alterations in intestinal genes related to anabolic and catabolic lipid metabolism pathways. Overall, the results demonstrate that during obesity and a HFD, the intestinal mucosa exhibits metabolic dysfunction. There is indirect evidence that the lipolytic enzyme monoacylglycerol lipase (MGL) may be involved in the development of obesity. We therefore examined the role of MG metabolism in energy homeostasis using wild type and MGL-/- mice fed low-fat or high-fat diets for 12 weeks. Tissue MG species were profoundly increased, as expected. Notably, weight gain was blunted in all MGL-/- mice. MGL null mice were also leaner, and had increased fat oxidation on the low-fat diet. Circulating lipids levels were decreased in high fat-fed MGL-/- mice, as were the levels of several plasma peptides involved in energy homeostasis. Interestingly, MGL-/- mice had a blunted rate of intestinal TG secretion following an oral fat challenge. The leaner phenotype and improved metabolic serum profile in MGL-/- mice suggested that pharmacological inhibition may be a potential treatment for metabolic disease. To further examine this, C57BL6/J mice were fed low-fat and high-fat diets for 12 weeks, and then given daily oral administration of vehicle or a novel reversible MGL inhibitor for 4 days or 27 days. No changes in food intake were found, nor were adiposity or glucose intolerance substantially altered by inhibitor treatment; this is likely due to the short-term effectiveness of the inhibitor, as the compound was barely detectable 7 hours following administration. Thus, the effects of transient MGL inhibition on energy metabolism are minimal, in contrast to chronic inhibition secondary to genetic ablation.
Subject (authority = RUETD)
Topic
Nutritional Sciences
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_5264
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xiv, 164 p. : ill.
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = vita)
Includes vita
Note (type = statement of responsibility)
by John David Douglass
Subject (authority = ETD-LCSH)
Topic
Obesity
Subject (authority = ETD-LCSH)
Topic
Nutrition disorders
Subject (authority = ETD-LCSH)
Topic
Lipids in human nutrition
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3D798HP
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Douglass
GivenName
John
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2014-01-01 15:15:55
AssociatedEntity
Name
John Douglass
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2014-01-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2015-01-31
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after January 31st, 2015.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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