RUcore: Rutgers University Community Repository
Defining the nanoRNA regulon and the mechanism by which gene expression is controlled and manifested
Descriptive
TitleInfo
Title
Defining the nanoRNA regulon and the mechanism by which gene expression is controlled and manifested
Name
(type = personal)
NamePart
(type = family)
Hammond
NamePart
(type = given)
Gifty Naa Ayeley
NamePart
(type = date)
1981-
DisplayForm
Gifty Hammond
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Vershon
NamePart
(type = given)
Andrew
DisplayForm
Andrew Vershon
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Woychik
NamePart
(type = given)
Nancy
DisplayForm
Nancy Woychik
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Nickels
NamePart
(type = given)
Bryce
DisplayForm
Bryce Nickels
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2014
DateOther
(qualifier = exact);
(type = degree)
2014-01
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Gene transcription is mediated by the enzyme RNA polymerase (RNAP). RNAP is a multi subunit nucleotidyl transferase that polymerizes ribonucleotides at the 3’ end of an RNA transcript. Transcription by RNAP typically occurs by de novo transcription initiation whereby nucleoside triphosphates (NTPs) initiate transcription. Small RNAs of approximately 2-5 nucleotides have long been known to successfully prime transcription in vitro. In published work, the Nickels lab has established that these small RNAs (nanoRNAs) successfully compete with NTPs for transcription priming of some genes in vivo. NanoRNA-mediated priming alters the position of transcription initiation and possibly has a vital role in the regulation of gene expression. The complete set of genes whose expression is affected by nanoRNA-mediated priming remains to be elucidated. I propose to define the nanoRNA regulon and the mode by which gene expression is controlled and manifested. I will use a variety of molecular and biochemical in vivo and in vitro methods to determine the nanoRNA-mediated priming impact on gene expression.
Subject
(authority = RUETD)
Topic
Microbiology and Molecular Genetics
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_5277
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
iii, 30 p. : ill.
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Gifty Naa Ayeley Hammond
Subject
(authority = ETD-LCSH)
Topic
Gene expression
Subject
(authority = ETD-LCSH)
Topic
Genetic regulation
Subject
(authority = ETD-LCSH)
Topic
Reverse transcriptase
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Location
PhysicalLocation
(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3G73BSF
Genre
(authority = ExL-Esploro)
ETD graduate
Back to the top
Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Hammond
GivenName
Gifty
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2014-01-02 15:19:48
AssociatedEntity
Name
Gifty Hammond
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
Back to the top
Technical
RULTechMD
(ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem
(VERSION = 5.1)
windows xp
Back to the top
Statistical Profile