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Spatial training in the Morris water maze induces differential changes in interleukin-1 beta(IL-1β) expression in hippocampal and extra-hippocampal tissue
Descriptive
TitleInfo
Title
Spatial training in the Morris water maze induces differential changes in interleukin-1 beta(IL-1β) expression in hippocampal and extra-hippocampal tissue
Name
(type = personal)
NamePart
(type = family)
Mallimo
NamePart
(type = given)
Elyse M
NamePart
(type = date)
1985-
DisplayForm
Elyse Mallimo
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Kusnecov
NamePart
(type = given)
Alexander
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Alexander Kusnecov
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Wagner
NamePart
(type = given)
George
DisplayForm
George Wagner
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Otto
NamePart
(type = given)
Tim
DisplayForm
Tim Otto
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Pintar
NamePart
(type = given)
John
DisplayForm
John Pintar
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2014
DateOther
(qualifier = exact);
(type = degree)
2014-01
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
It is now well accepted that the brain and the immune system are intimately linked and that cytokines, small proteins secreted by cells of the immune system, exert diverse effects on CNS function. Of particular importance in this regard is the proinflammatory cytokine interleukin-1 beta (IL-1β) which is critically involved in peripheral and central inflammatory responses. Although early research surrounding the biological effects of IL-1β has focused on its detrimental role in cognitive function, emerging data strongly suggest that physiologically-low levels of IL-1β are required for hippocampal-dependent learning and long-term memory formation. In light of these observations, the present series of experiments were conducted in order to better characterize the spatio-temporal expression of IL-1β during spatial learning in the Morris water maze (MWM). To that end, IL-1β (protein) expression was measured in the dorsal hippocampus at different time points and after one or three sessions of spatial training in the MWM (experiment 1). Moreover, because spatial navigation may depend on a distributed network of structures besides the hippocampus, IL-1β expression was also measured in the prefrontal cortex (PFC). Results from experiment 1 are suggestive of a coordinated modulation of IL-1β between the dorsal hippocampus and PFC that persists for at least the first three days of spatial training. In light of these observations and because microglial cells represent a primary source of IL-1β in the CNS, experiment 2 was conducted in order to determine whether learning induced changes in microglial activation. Results from experiment 2 reveal a training-specific downregulation of microglial cell activity in the PFC and are in agreement with a physiological role for microglia in the normal healthy brain. Finally, a third experiment was conducted in order to determine whether massed spatial training induces the expression of IL-1β, and other components of the IL-1 system.
Subject
(authority = RUETD)
Topic
Psychology
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_5278
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
ix, 177 p. : ill.
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Elyse M Mallimo
Subject
(authority = ETD-LCSH)
Topic
Central nervous system--Immunology
Subject
(authority = ETD-LCSH)
Topic
Cytokines
Subject
(authority = ETD-LCSH)
Topic
Interleukin-1
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Location
PhysicalLocation
(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3348HGX
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Mallimo
GivenName
Elyse
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2014-01-02 16:36:52
AssociatedEntity
Name
Elyse Mallimo
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
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ContentModel
ETD
OperatingSystem
(VERSION = 5.1)
windows xp
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