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The protection of ultraviolet sensitive molecules through polymeric encapsulation and proximity

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TitleInfo
Title
The protection of ultraviolet sensitive molecules through polymeric encapsulation and proximity
Name (type = personal)
NamePart (type = family)
Steeley
NamePart (type = given)
Kristin Gilida
NamePart (type = date)
1986-
DisplayForm
Kristin Steeley
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Shapley
NamePart (type = given)
Nina C
DisplayForm
Nina C Shapley
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Ramachandran
NamePart (type = given)
Rohit
DisplayForm
Rohit Ramachandran
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Chiew
NamePart (type = given)
Yee C
DisplayForm
Yee C Chiew
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Fabris
NamePart (type = given)
Laura
DisplayForm
Laura Fabris
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2014
DateOther (qualifier = exact); (type = degree)
2014-01
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Exposure to ultraviolet (UV) radiation causes many materials to undergo chemical reactions leading to degradation. While the negative impact of UV radiation on human skin remains in the spotlight, many commercial products have also proven to be photosensitive, leading to the desire to protect molecules from photodegradation. The most common method of UV protection is to add protective materials such as UV absorbers or antioxidants to a formulation. Encapsulation of a photosensitive molecule is also a proven method of photoprotection. In this work, novel UV protective systems were created by encapsulating a photosensitive molecule, beta-carotene, in various polymer particle geometries with protectant molecules. The goal of this dissertation was to use such systems to examine the effect of proximity between photosensitive and UV protecting molecules. Uniform particles were initially created in order to quantify the effect of encapsulation and to study the result of encapsulating beta-carotene with UV absorbers (oxybenzone, avobenzone, and octyl-4-methoxycinnamate (OMC)) and an antioxidant (vitamin E) in a polymer matrix. Particles were synthesized by the solvent evaporation method. UV protection was found to be dependent on the protectant added and the concentration of the protectant, except in the case of OMC. The most effective particle formulation contained both oxybenzone and vitamin E. Experimental designs were created to discover the proper composition and procedure for synthesizing various core-shell particle geometries. These core-shell particles were used to study the effect of proximity on UV protection. The core-shell particles themselves offered more protection than the uniform particles, and in most cases the addition of a protectant increased UV protection. Splitting the protectant concentration between the core and shell did not have a significant effect in most cases. The optimal formulation consisted of a suspension of polymer particles containing vitamin E and beta-carotene in the particle core and a UV absorber in the particle shell. Other particle characteristics were studied, including particle size and shell thickness, and were found to have minimal effect. The core-shell particles provide a new protective system for photosensitive molecules as well as a method of studying the effect of proximity on UV protection.
Subject (authority = RUETD)
Topic
Chemical and Biochemical Engineering
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_5213
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xviii, 176 p. : ill.
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Kristin Gilida Steeley
Subject (authority = ETD-LCSH)
Topic
Ultraviolet radiation--Physiological effect
Subject (authority = ETD-LCSH)
Topic
Beta carotene
Subject (authority = ETD-LCSH)
Topic
Antioxidants
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3BZ644K
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Steeley
GivenName
Kristin
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2013-12-16 11:50:27
AssociatedEntity
Name
Kristin Steeley
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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