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Antimicrobial and rheological properties of benzoyl peroxide formulated polycarbophil/carbomer 934P hydrogel

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TitleInfo
Title
Antimicrobial and rheological properties of benzoyl peroxide formulated polycarbophil/carbomer 934P hydrogel
Name (type = personal)
NamePart (type = family)
Xu
NamePart (type = given)
Shiqi
NamePart (type = date)
1987-
DisplayForm
Shiqi Xu
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
HUANG
NamePart (type = given)
QINGRONG
DisplayForm
QINGRONG HUANG
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Chikindas
NamePart (type = given)
Michael L
DisplayForm
Michael L Chikindas
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
co-chair
Name (type = personal)
NamePart (type = family)
Rogers
NamePart (type = given)
Michael A
DisplayForm
Michael A Rogers
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2014
DateOther (qualifier = exact); (type = degree)
2014-01
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
BACKGROUND: The human vagina is colonized by a variety of indigenous microflora; in healthy individuals Lactobacillus is a predominant bacterial genus while those with bacterial vaginosis (BV) carry a variety of anaerobic bacteria. The disruption of healthy microflora and shift to primarily facultative anaerobic bacteria leads to microbial disease. Benzoyl peroxide (BPO) is chosen as a new antimicrobial agent since it is listed as safe for use in bleaching in food product and as an active ingredient of acne topical treatments. Polycarbophil/Carbomer 934P are chosen to be the network polymers of the hydrogel to encapsulate BPO, due to their good muco-adhesion. EXPERIMENTS: In this study, the antimicrobial activity of BPO against Gardnerella vaginalis, one of the primary causative agent of BV, and their safety for vaginal lactobacilli such as L. acidophilus, L. gasseri, L. plantarum, and L. vaginalis is evaluated using a well diffusion assay, direct contact assay and diffusible agent assay. The rheological properties of the formulations are measured using an oscillation frequency sweep, an oscillation shear stress sweep and a flow shear rate experimental design. RESULTS: It is shown that in the well diffusion assay G. vaginalis is inhibited at 0.01% (w/w) hydrogel-encapuslated BPO and that the tested Lactobacillus spp. are inhibited at 2.5%. In direct contact assays (cells grown in a liquid culture containing hydrogel, hydrogel containing 1.0% BPO or BPO particles), hydrogels loaded with 1.0% BPO caused 6-log reduction of G. vaginalis. Conversely, three of the lactobacilli spp. are not inhibited while L. acidophilus growth is delayed. Encapsulation of BPO into polycarbophil/Carbomer 934P hydrogel improves its antimicrobial activity against G. vaginalis. The rheological properties of the hydrogel formulation are not greatly compromised by encapsulation of 1.0% BPO. The new formulation still possesses a solid-like behavior, with a low yield stress and a high viscosity after diluted. CONCLUSION: Hydrogel containing BPO can be a new drug in BV treatment based on its antimicrobial activity on BV-associated pathogen/not on healthy vaginal lactobacilli when it is encapsulated into polycarbophil/Carbomer 934P hydrogel, and its good rheological properties.
Subject (authority = RUETD)
Topic
Food Science
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_5187
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
ix, 73 p. : ill.
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Shiqi Xu
Subject (authority = ETD-LCSH)
Topic
Vagina--Diseases--Treatment
Subject (authority = ETD-LCSH)
Topic
Shear flow
Subject (authority = ETD-LCSH)
Topic
Benzene in the body
Subject (authority = ETD-LCSH)
Topic
Colloids
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3K935MR
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Xu
GivenName
Shiqi
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2013-12-05 21:31:26
AssociatedEntity
Name
Shiqi Xu
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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