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Improve bioaccessibility of quercetin using pseudo-organogel based nanoemulsions

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TitleInfo
Title
Improve bioaccessibility of quercetin using pseudo-organogel based nanoemulsions
Name (type = personal)
NamePart (type = family)
Xu
NamePart (type = given)
Xuechen
NamePart (type = date)
1988-
DisplayForm
Xuechen Xu
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
HUANG
NamePart (type = given)
QINGRONG
DisplayForm
QINGRONG HUANG
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Rogers
NamePart (type = given)
Michael A.
DisplayForm
Michael A. Rogers
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
HO
NamePart (type = given)
CHI-TANG
DisplayForm
CHI-TANG HO
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2014
DateOther (qualifier = exact); (type = degree)
2014-01
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Flavonoids which are widely distributed in plants can be categorized as flavonols, flavanols, flavanones, flavones, anthocyanidin and isoflavones. Quercetin (3, 3’, 4’, 5, 7-pentahydroxylflavone) accounts for the largest percentage of flavonol intake in the diet. Like many other flavonoids, quercetin has many health-promotion and disease-prevention benefits. However, its low solubility in water and gastric fluid leads to a low bioavailability in vivo. Lipid-based formulations, such as O/W nanoemulsions and solid lipid nanoparticles have been developed to increase the bioaccessibility of flavonoids. Modern delivery systems such as organogel or pseudo-organogel based emulsions have not yet been studied as quercetin delivery vehicles. In this study, pseudo-organogel and pseudo-organogel based emulsion systems have been developed for oral delivery of quercetin to improve its bioaccessibility. The formation of pseudo-organogel inhibited quercetin crystallization in the oil phase. Using mixture of limonene and medium chain triglyceride (MCT) at the ratio of 2:8 (w/w), solubility of quercetin was increased by 40 times compared to quercetin in MCT at room temperature. Bioaccessibility and the extent of lipolysis were determined for the pseudo-organogel based emulsion system. After the first 30 min of digestion, the extent of lipolysis of the pseudo-organogel based emulsion (71.9 %±1.2 %) was significantly higher (p<0.001) than that of the quercetin loaded oil mixture (same oil mixture as that used to form pseudo-organogel based emulsion) (54.0 %±0.6 %). The percentages of bioaccessibility of quercetin in oil mixture and in pseudo-organogel based emulsion were determined to be (35.6 % ± 0.6 %) and (49.7%±5.3%) respectively, which were significantly higher than that of quercetin in water suspension (less than 3 %). With a higher and stable loading of quercetin, and the improved bioaccessibility, this pseudo-organogel based emulsion system of quercetin may have potential applications in food, cosmetic and pharmaceutical industries.
Subject (authority = RUETD)
Topic
Food Science
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_5315
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
x, 43 p. : ill.
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Xuechen Xu
Subject (authority = ETD-LCSH)
Topic
Quercetin
Subject (authority = ETD-LCSH)
Topic
Flavonoids
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3FJ2DVK
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Xu
GivenName
Xuechen
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2014-01-10 08:22:35
AssociatedEntity
Name
Xuechen Xu
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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