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Hippocampal neural firing dynamics during sleep
Descriptive
TitleInfo
Title
Hippocampal neural firing dynamics during sleep
Name
(type = personal)
NamePart
(type = family)
Grosmark
NamePart
(type = given)
Andres D.
NamePart
(type = date)
1984-
DisplayForm
Andres Grosmark
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Krekelberg
NamePart
(type = given)
Bart
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Bart Krekelberg
Affiliation
Advisory Committee
Role
RoleTerm
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chair
Name
(type = personal)
NamePart
(type = family)
Paré,
NamePart
(type = given)
Denis
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Denis Paré,
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
György
NamePart
(type = given)
György
DisplayForm
György György
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Creese
NamePart
(type = given)
Ian
DisplayForm
Ian Creese
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Battaglia
NamePart
(type = given)
Francesco
DisplayForm
Francesco Battaglia
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - Newark
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
Genre
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ETD doctoral
OriginInfo
DateCreated
(qualifier = exact)
2014
DateOther
(qualifier = exact);
(type = degree)
2014-05
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
The focus of my thesis was the assessment of the presence and dynamics of non-specific, putatively homeostatic, as well as specific memory-related, modifications in the structure of hippocampal firing patterns during sleep. As a step toward understanding sleep function, I developed an appropriate, open-source Matlab-based application for the visualization, annotation and detailed sleep scoring of long-time scale electrophysiological data relevant to brain state dynamics. In my study of putatively homeostatic changes in excitability I found that the overall firing rates of hippocampal CA1 neurons decreased across sleep concurrent with an increased recruitment of neuronal spiking to brief ‘ripple’ episodes, resulting in a net increase in neural synchrony. Unexpectedly, within non-REM episodes overall firing rates were found to gradually increase together with a decrease in recruitment of spiking to ripples. The rate increase within non-REM rate episodes was counteracted by a larger rapid decrease of discharge frequency during the interleaving REM episodes. Both the decreasing firing rates and the increasing synchrony during the course of sleep were correlated with the power of theta activity during REM episodes. These findings suggest a prominent role of REM sleep in sleep-related neuronal plasticity. Lastly, in order to gauge the interaction between non-specific and memory-specific contributions to sleep-related firing dynamics, I recorded hours of sleep in rats before and after exposure to a completely novel maze environment. While both replay and 'pre-play' were observed, both were found to be dominated by non-local (different silicon-probe shank) interactions. However, while replay was observed in both pair-wise and higher-order interactions, pre-play was surprisingly specifically restricted to higher-order sequential interactions. This analysis also included the assessment of several traditional as well as novel methods for measuring replay, leading to significant methodological insights into their sensitivity to the established non-stationary nature of excitability in sleep, and to several suggestions for future work.
Subject
(authority = RUETD)
Topic
Neuroscience
Subject
(authority = ETD-LCSH)
Topic
Hippocampus (Brain)
Subject
(authority = ETD-LCSH)
Topic
Sleep--Physiological aspects
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - Newark Electronic Theses and Dissertations
Identifier
(type = local)
rucore10002600001
Identifier
ETD_5615
Identifier
(type = doi)
doi:10.7282/T3K072J1
PhysicalDescription
Form
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electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
vii, 182 p. : ill.
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = vita)
Includes vita
Note
(type = statement of responsibility)
by Andres D. Grosmark
Location
PhysicalLocation
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Grosmark
GivenName
Andres
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2014-04-30 13:39:44
AssociatedEntity
Name
Andres Grosmark
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - Newark
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
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ContentModel
ETD
OperatingSystem
(VERSION = 5.1)
windows xp
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Statistical Profile