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A longitudinal analysis of medium spiny neuron activity in dorsolateral striatum during chronic cocaine self-administration
Descriptive
TitleInfo
Title
A longitudinal analysis of medium spiny neuron activity in dorsolateral striatum during chronic cocaine self-administration
Name
(type = personal)
NamePart
(type = family)
Coffey
NamePart
(type = given)
Kevin R.
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Kevin Coffey
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(authority = RULIB)
author
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(type = personal)
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(type = family)
Vicario
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(type = given)
David
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David Vicario
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Advisory Committee
Role
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(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
West
NamePart
(type = given)
Mark O
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Mark O West
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Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
McGann
NamePart
(type = given)
John
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John McGann
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Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
McCarthy
NamePart
(type = given)
Danielle
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Danielle McCarthy
Affiliation
Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
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(authority = RULIB)
school
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Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2014
DateOther
(qualifier = exact);
(type = degree)
2014-05
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Substance abuse is defined by continued consumption of drugs despite their negative consequences, and its treatment is plagued by exceptionally high relapse rates (40-60%). Current behavioral and neurobiological theories of substance abuse predict that with chronic use, drug consumption becomes habitual and neural activity shifts from the nucleus accumbens (NAc) to the dorsolateral Striatum (DLS). In the present study, we sought to test the latter theory: that in the course of chronic cocaine self-administration, DLS neurons acquire phasic patterns of firing in relation to drug-taking behaviors. We recorded from single body part (SBP) neurons in DLS that are specifically related to vertical head movement, (i.e. neck or head sensitive neurons) as well as a control group of non-SBP neurons. Animals self-administered cocaine using a vertical head movement operant and exhibited behavioral evidence of skilled self-administration. To analyze changes in neural firing rate (FR) across cocaine self-administration, we developed a custom generalized mixed model (2x2x12) with 2 levels of Neuron Type (Head Movement and Control), 2 levels of Firing Type (Phasic and Baseline) and 12 levels of recording Session. Baseline (non-movement) FR decreased in DLS neurons across days, but this decrease was confined to Head Movement neurons. Phasic (during head movements) FR differed significantly across sessions in both Head Movement and Control neurons. However, Phasic FR was significantly greater than Baseline FR only in Head Movement neurons, during the first two weeks (Days 3-4, 9-10, and 11-12). In the last two weeks, the population of Head Movement neurons in DLS contributed less to drug-taking behavior. Inconsistent with the tested theory, DLS does not become globally more active with chronic cocaine SA. Instead, chronic cocaine self-administration is related to a decrease in DLS activity, specifically in neurons that process the skill required for self-administering. Consistent with the tested hypothesis however, a small number of neurons acquired progressively more robust head movement activity after 24+ days of self-administration. During abstinence, these neurons could be responsible for processing or executing relapse behaviors.
Subject
(authority = RUETD)
Topic
Psychology
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_5327
PhysicalDescription
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(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Note
Supplementary File: Body Exam Example
Extent
vi, 45 p. : ill.
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Kevin R. Coffey
Subject
(authority = ETD-LCSH)
Topic
Cocaine abuse--Complications--Longitudinal studies
Subject
(authority = ETD-LCSH)
Topic
Movement disorders--Longitudinal studies
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
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rucore19991600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3QC01TK
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
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The author owns the copyright to this work.
RightsHolder
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Name
FamilyName
Coffey
GivenName
Kevin
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(qualifier = exact);
(point = start)
2014-02-07 15:09:29
AssociatedEntity
Name
Kevin Coffey
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
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Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime
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(qualifier = exact);
(point = start)
2014-05-31
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = end)
2014-11-30
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after November 30th, 2014.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
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ContentModel
ETD
OperatingSystem
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windows xp
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