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The feasibility of the utilization of drop-on-demand technology in the fabrication of flexible dosing, poly-pharmacy, and novel multi-drug design dosage forms

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TitleInfo
Title
The feasibility of the utilization of drop-on-demand technology in the fabrication of flexible dosing, poly-pharmacy, and novel multi-drug design dosage forms
Name (type = personal)
NamePart (type = family)
Brown
NamePart (type = given)
Marlena
DisplayForm
Marlena Brown
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Takhistov
NamePart (type = given)
Paul
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Paul Takhistov
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Michniak-Kohn
NamePart (type = given)
Bozena
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Bozena Michniak-Kohn
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Advisory Committee
Role
RoleTerm (authority = RULIB)
co-chair
Name (type = personal)
NamePart (type = family)
Shreiber
NamePart (type = given)
David
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David Shreiber
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Harris
NamePart (type = given)
Michael
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Michael Harris
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2014
DateOther (qualifier = exact); (type = degree)
2014-05
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Current and future trends in the delivery of Active Pharmaceutical Ingredients (API) have led to an explosion into the research of the development and understanding of novel drug delivery systems with the capacity to delivery drugs with increasing accuracy and efficiency. The advent of the discoveries made in the human genome project enables genetic and anthropometric information about individuals to be utilized to deliver tailored strategies for the detection, treatment, and prevention of disease. Microdispensing and, in particular, Drop-on-Demand (DoD) technology, is an optimum technology to employ in this avenue because it allows for the delivery of customizable drug architecture due to its innovative and modular design. DoD enables customization for use in personalized medicine because it is based upon a building block methodology where the dosage and the drug delivery system is adapted by determining key attributes and combining the Active Pharmaceutical Ingredient (API) and polymer in a block matrix system. The goal of this research is to examine the feasibility of the utilization of Drop-on-Demand (DoD) technology to manufacture drugs that enable flexible dosing, poly-pharmacy, and multi-drug design dosage forms. Applied to transdermal drug delivery, we wish to design Transdermal Drug Delivery Systems (TDDS) in an innovative and systematic approach. We propose to (1) print multi drug dosage forms, (2) decrease the amount of layers currently used in the traditional system, and (3) create new dosage forms by printing the API, skin enhancers, additives, and adhesive components onto the same film with distinct patterns and configurations to achieve the desired dissolution results.
Subject (authority = RUETD)
Topic
Biomedical Engineering
Subject (authority = ETD-LCSH)
Topic
Drug delivery systems
Subject (authority = ETD-LCSH)
Topic
Pharmaceutical technology
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_5524
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xii, 167 p. : ill.
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Marlena Brown
Subject (authority = ETD-LCSH)
Topic
Drugs--Dosage forms
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3FT8JBJ
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Brown
GivenName
Marlena
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2014-04-15 15:11:10
AssociatedEntity
Name
Marlena Brown
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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RULTechMD (ID = TECHNICAL1)
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ETD
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windows xp
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