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Development and validation of a purge & trap- thermal desorption-gas chromatography-mass spectrometry method for the determination of propylene chlorohydrins (PCH) in hydroxpropyl starch and/or propylene oxide fumigated food products
Descriptive
TitleInfo
Title
Development and validation of a purge & trap- thermal desorption-gas chromatography-mass spectrometry method for the determination of propylene chlorohydrins (PCH) in hydroxpropyl starch and/or propylene oxide fumigated food products
Name
(type = personal)
NamePart
(type = family)
Ji
NamePart
(type = given)
Yue
NamePart
(type = date)
1989-
DisplayForm
Yue Ji
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Hartman
NamePart
(type = given)
Thomas G
DisplayForm
Thomas G Hartman
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Schaich
NamePart
(type = given)
Karen M
DisplayForm
Karen M Schaich
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
HO
NamePart
(type = given)
CHITANG
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CHITANG HO
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2014
DateOther
(qualifier = exact);
(type = degree)
2014-05
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Propylene oxide has been widely used in food industry to modify food functionality and to sterilize food products. Examples include hydroxypropylation of starch and cellulose to modify cold water solubility and sterilization of nutmeat like almonds. In this process, some undesirable side chemicals such as PCH are produced. PCH are mutagens and potential carcinogens. The level of PCH permissible in modified starch is regulated internationally. Food Chemical Codex, Joint FAO/WHO Expert Committee on Food Additives (JECFA) and European Commission on food additives have set the limit of PCH in hydroxypropyl starch, which is less than 1mg/kg. However, because few toxicology guideline studies are available on PCH, the hazardous effects have not been fully understood and the allowable residue content of PCH in many food products has not been specified by regulations. Recent independent studies conducted in the US and Europe have suggested that the certified international method for PCH quantification in modified starch may underestimate the amount of residual PCH. The objective of this research is to develop an alternate method for PCH quantification and to independently evaluate the results of a newly proposed solvent extraction GC-MS analytical method (AVEBE unpublished study). The P&T-TD-GC-MS method includes four steps: solvent extraction with water or MEOH, Purge & Trap concentration, thermal desorption and GC-MS analysis. It incorporates 3-chloro-1-propanol (a PCH structural isomer) as a matrix-spiked internal standard. The method is approximately 100 times more sensitive than the proposed European solvent extraction-GC-MS method, allowing for full-scan mass confirmation in contrast to the European method that uses selected ion monitoring. The P&T-TD-GC-MS method also eliminated the requirement of a highly specific GC injector (Programmed Thermal Volatilizer or PTV) which is mandated by the European method and not commonly available to most labs. With this P&T-TD-GC-MS method, the LOD of both PCH1 and PCH2 is 0.025mg/kg and their LOQ is 0.1 mg/kg. A series of method validation tests, including precision, system suitability and recovery were conducted to determine the accuracy and sensitivity of the P&T-TD-GC-MS method in this study.
Subject
(authority = RUETD)
Topic
Food Science
Subject
(authority = ETD-LCSH)
Topic
Propylene oxide
Subject
(authority = ETD-LCSH)
Topic
Food--Toxicology
Subject
(authority = ETD-LCSH)
Topic
Food adulteration and inspection
Subject
(authority = ETD-LCSH)
Topic
Carcinogenicity testing
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Identifier
ETD_5386
Identifier
(type = doi)
doi:10.7282/T35X277R
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
ix, 81 p. : ill.
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Yue Ji
Location
PhysicalLocation
(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Ji
GivenName
Yue
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2014-04-04 22:15:15
AssociatedEntity
Name
Yue Ji
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
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ContentModel
ETD
OperatingSystem
(VERSION = 5.1)
windows xp
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Statistical Profile