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Macro and micro characterization of powder mixing processes

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TitleInfo
Title
Macro and micro characterization of powder mixing processes
Name (type = personal)
NamePart (type = family)
Osorio Caicedo
NamePart (type = given)
Juan Guillermo
NamePart (type = date)
1985-
DisplayForm
Juan Osorio Caicedo
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Muzzio
NamePart (type = given)
Fernando J
DisplayForm
Fernando J Muzzio
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Ierapetritou
NamePart (type = given)
Marianthi
DisplayForm
Marianthi Ierapetritou
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Ramachandran
NamePart (type = given)
Rohit
DisplayForm
Rohit Ramachandran
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Litster
NamePart (type = given)
James D
DisplayForm
James D Litster
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2014
DateOther (qualifier = exact); (type = degree)
2014-05
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Powder mixing is a critical operation in pharmaceuticals and other industries. Despite much research, there is still a lack of understanding of the mixing mechanisms, their effects on blend properties, and how these affect the quality of the final product. In addition, commonly used and new batch mixing technologies are not well established to handle the growing number of products involving cohesive and highly potent active pharmaceutical ingredients (APIs). The work presented in this dissertation focuses on the macro- and micro-mixing characterization of a resonant acoustic mixer (RAM), and the micro-mixing dynamic characterization of bin-blending for pharmaceutical powders, with an emphasis on mixing cohesive APIs. First, the mixing performance of the RAM as a function of processing parameters (acceleration, fill level and blending time) was characterized. Then the effects of the RAM processing parameters on the final blend properties, and tableting and tablet characteristics were investigated. This was followed by the micro-mixing characterization of blends obtained from the RAM using near-infrared chemical imaging (NIR-CI). In the second part of this dissertation, the micro-mixing dynamics of three APIs, chlorpheniramine maleate (very cohesive), acetaminophen (cohesive) and caffeine (slightly cohesive), were characterized using in situ NIR-CI and compared. Overall, blends in the RAM reached the required blend uniformity (RSD < 5%) in as low as 30 seconds. Resonant acoustic mixing significantly affected the final properties of lubricated blends, increasing their density with increases in acceleration and blending time. These changes in blend properties affected the final properties of tablets by increasing weight, decreasing hardness, and decreasing dissolution. All blend and tablet properties, except hydrophobicity, followed a power law when correlated to the energy per unit mass. The aggregation of the API in the blends decreased with increasing mixing intensity (acceleration) and blending time. In the bin-blending studies, the most cohesive API followed the expected trends (e.g. higher RSDs and larger aggregate sizes), while the trends for APAP and caffeine were dependent on their concentrations. NIR-CI was useful in monitoring the distribution and aggregate size of APIs and excipients, demonstrating agglomeration as a function of cohesion and API concentration in the blends.
Subject (authority = RUETD)
Topic
Chemical and Biochemical Engineering
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_5364
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xvii, 250 p. : ill.
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Juan Guillermo Osorio Caicedo
Subject (authority = ETD-LCSH)
Topic
Powders--Mixing
Subject (authority = ETD-LCSH)
Topic
Powders (Pharmacy)--Mixing
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3NK3CB1
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Osorio Caicedo
GivenName
Juan
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2014-03-24 19:49:20
AssociatedEntity
Name
Juan Osorio Caicedo
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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