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Milk-borne bioactive factors

Descriptive

TitleInfo
Title
Milk-borne bioactive factors
SubTitle
effects on neonatal porcine reproductive tissues
Name (type = personal)
NamePart (type = family)
Rahman
NamePart (type = given)
Kathleen M.
NamePart (type = date)
1986-
DisplayForm
Kathleen Rahman
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Bagnell
NamePart (type = given)
Carol A.
DisplayForm
Carol A. Bagnell
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Watford
NamePart (type = given)
Malcolm
DisplayForm
Malcolm Watford
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Uzumcu
NamePart (type = given)
Mehmet
DisplayForm
Mehmet Uzumcu
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Bartol
NamePart (type = given)
Frank F.
DisplayForm
Frank F. Bartol
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2014
DateOther (qualifier = exact); (type = degree)
2014-05
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Milk-borne bioactive factors (MbFs) are delivered to nursing offspring via a lactocrine mechanism to affect development of somatic tissues, including the uterus. In the pig, lactocrine-sensitive events associated with postnatal uterine development between birth (postnatal day = PND 0) and PND 2 define the developmental program and can determine developmental trajectory and function. However, lactocrine-sensitive elements of the neonatal porcine uterine transcriptome have not been defined during this period. The extent to which MbFs, including insulin-like growth factor (IGF)-I, affect development of the porcine uterus postnatally is unknown. Furthermore, whether nursing supports testicular development in pigs by PND 2 remains to be determined. Research goals were to (1) define the lactocrine-sensitive uterine transcriptome in nursed gilts compared to animals fed replacer from birth until PND 2; (2) determine whether feeding colostrum, with or without IGF-I supplementation, supports endometrial cell proliferation at 12 h postnatal; and (3) assess whether nursing affects Sertoli and Leydig cell development as well as expression of markers important for testicular development within two days after birth. Results showed that in uteri of nursed as compared to replacer-fed gilts, 896 genes were differentially expressed and multiple elements of biological processes and pathways affected by PND 2. Additionally, data indicated that when compared to replacer-fed gilts, a single dose of colostrum at birth increased endometrial cell proliferation at 12 h postnatal. Furthermore, oral IGF-I increased uterine cell proliferation when co-administered with replacer, but not with colostrum. Sertoli cell number and proliferation were increased in boars nursed for two days compared to newborn or replacer-fed boars at PND 2. However, testicular RXFP1 expression was increased in replacer-fed animals as compared to boars collected at birth or after two days of nursing. Collectively, data presented here reinforce and extend previous findings that lactocrine signaling supports neonatal porcine reproductive development. Results can be used to refine and focus the lactocrine hypothesis to identify key MbFs as well as cellular and molecular mechanisms that regulate postnatal male and female reproductive development in the pig.
Subject (authority = RUETD)
Topic
Animal Sciences
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_5373
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
x, 125 p. : ill.
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Kathleen M. Rahman
Subject (authority = ETD-LCSH)
Topic
Milk--Composition
Subject (authority = ETD-LCSH)
Topic
Testis
Subject (authority = ETD-LCSH)
Topic
Swine--Development--Endocrine aspects
Subject (authority = ETD-LCSH)
Topic
Biotransformation (Metabolism)
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3C53J57
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Rahman
GivenName
Kathleen
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2014-04-02 13:41:53
AssociatedEntity
Name
Kathleen Rahman
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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