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Design of polymeric nanoparticles for edible antimicrobials and chemical oxygen sensors

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TitleInfo
Title
Design of polymeric nanoparticles for edible antimicrobials and chemical oxygen sensors
Name (type = personal)
NamePart (type = family)
Sun
NamePart (type = given)
Shiwen
NamePart (type = date)
1989-
DisplayForm
Shiwen Sun
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Shapley
NamePart (type = given)
Nina
DisplayForm
Nina Shapley
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Chiew
NamePart (type = given)
Yee
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Yee Chiew
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Dutt
NamePart (type = given)
Meenakshi
DisplayForm
Meenakshi Dutt
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Matthews
NamePart (type = given)
Karl
DisplayForm
Karl Matthews
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2014
DateOther (qualifier = exact); (type = degree)
2014-05
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Research and development of nanoscale materials have received increasing attention due to the small size scales and large surface-volume ratios involved, and the associated changes in properties compared to those of bulk systems. This dissertation introduces the design of two types of polymeric nanoparticles, intended for edible antimicrobials or for chemical oxygen sensors. Recent outbreaks of foodborne pathogens have attracted public attention to food safety. Due to healthy life style trends, there is a demand for the development of an efficient, biocompatible sanitizing method for fresh and fresh-cut produce. We have developed chitosan-based nanoparticles modified with antimicrobial agents in order to achieve potent antimicrobial activity. Nisin, a widely used food preservative, has been attached to chitosan nanoparticles by electrostatic forces with a layer of anionic alginic acid in between. ε-poly-L-lysine, a natural and broad-spectrum antimicrobial, has been incorporated when forming chitosan nanoparticles. Particle properties have been studied, including the particle diameter, zeta potential, and morphology. Further investigation of antimicrobial activity is ongoing in Dr. Karl Matthews’ group in the Department of Food Science, including determination of the minimum inhibitory concentration, bacterial viability monitoring assays, and application in food washing steps. Oxygen is one of the most import analytes in the world due to its high relevance to living things. Determination of oxygen concentration has great importance in various fields. A series of new nanoparticle-based optical oxygen sensors were developed. The luminescent oxygen indicator dyes Pt(II)–5,15-di(pentafluorophenyl)-10,20-di(4-bromophenyl)porphyrin (PtTFPP), and Pt(II) meso-tetra(4-bromophenyl)tetra(tert-butyl)benzoporphyrin (PtTPTtBuBP) were covalently immobilized into two different conjugated polymers. The resulting polymers were rendered positively or negatively charged via chemical modification and were used to prepare oxygen-sensitive nanoparticles via a nanoprecipitation technique. This method improved the brightness of the oxygen sensor by a factor of 4-6. Efficient energy transfer was established from conjugated polymers to the oxygen indicator dye. Highly efficient two-photon excitation is expected. Different functional groups were also added to achieve adequate stability in aqueous dispersion and cell-penetration ability for different types of cells and tissues. Further investigation is ongoing in Dr. Dmitri Papkovsky’s group at University College Cork (Ireland).
Subject (authority = RUETD)
Topic
Chemical and Biochemical Engineering
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_5465
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xii, 80 p. : ill.
Note (type = degree)
M.S.T.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Shiwen Sun
Subject (authority = ETD-LCSH)
Topic
Nanoparticles
Subject (authority = ETD-LCSH)
Topic
Polymers
Subject (authority = ETD-LCSH)
Topic
Anti-infective agents
Subject (authority = ETD-LCSH)
Topic
Food handling
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3DV1H6Q
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Sun
GivenName
Shiwen
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2014-04-12 11:15:09
AssociatedEntity
Name
Shiwen Sun
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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