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Effects of age and acute submaximal exercise on inflammatory cytokines, cortisol, insulin, heat shock proteins and skeletal muscle mediators of energy homeostasis in horses

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TitleInfo
Title
Effects of age and acute submaximal exercise on inflammatory cytokines, cortisol, insulin, heat shock proteins and skeletal muscle mediators of energy homeostasis in horses
Name (type = personal)
NamePart (type = family)
Avenatti
NamePart (type = given)
Ryan Charles
NamePart (type = date)
1983-
DisplayForm
Ryan Avenatti
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Malinowski
NamePart (type = given)
Karyn
DisplayForm
Karyn Malinowski
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
McKeever
NamePart (type = given)
Kenneth H
DisplayForm
Kenneth H McKeever
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
co-chair
Name (type = personal)
NamePart (type = family)
Arent
NamePart (type = given)
Shawn M
DisplayForm
Shawn M Arent
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Horohov
NamePart (type = given)
David W
DisplayForm
David W Horohov
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Alway
NamePart (type = given)
Stephen
DisplayForm
Stephen Alway
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2014
DateOther (qualifier = exact); (type = degree)
2014-10
CopyrightDate (encoding = w3cdtf)
2014
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
There is a well documented decline in exercise capacity, immune function, insulin sensitivity and hypothalamic-pituitary-adrenal axis function in aged horses. Aerobic training can partially reverse age-related declines in performance measures, endocrine and immune function, and insulin sensitivity in horses. The mechanisms behind the adaptive response to exercise in horses require further research. Based on the comparative literature, several mediators of energy homeostasis and adaptation to exercise were identified for investigation in whole blood and skeletal muscle of horses. Young and aged unconditioned Standardbred mares underwent an acute submaximal exercise test. Plasma cortisol, insulin and glucose concentrations were determined pre- and post-exercise. Whole blood and gluteus medius biopsies were analyzed for gene expression of inflammatory cytokines, HSP70 and HSP90 pre- and post-exercise. Skeletal muscle was also analyzed for protein content of HSP70, HSP90, AMPK, Akt and AS160 pre- and post-exercise. Exercise increased plasma cortisol concentration in both young and aged mares, with the duration of the post-exercise rise in cortisol altered in aged horses. Although the magnitude of the insulin response to exercise was not different between young and aged horses, plasma insulin was elevated sooner and declined earlier in aged mares. Subsequently, aged mares had a shorter duration of elevated plasma glucose concentration post-exercise than young mares. Exercise increased IL-β expression in whole blood of young and aged mares, with young mares having greater exercise-induced expression of IL-β. Cytokine expression was not altered in skeletal muscle, regardless of age or exercise. Young and aged horses had increased HSP70 expression in whole blood following exercise, with young horses exhibiting greater exercise-induced HSP70 expression. HSP90 expression in whole blood following exercise was increased only in young horses. HSP70 and HSP90 expression in skeletal muscle was increased following exercise in both young and aged horses, with age altering the timing of HSP70 expression. There were no changes in skeletal muscle protein content of HSP70 and HSP90; or in activation or total protein concentration of AMPK, Akt and AS160, due to exercise or age. In conclusion, mediators of energy homeostasis and the adaptive response to exercise are altered with age in horses.
Subject (authority = RUETD)
Topic
Animal Sciences
Subject (authority = ETD-LCSH)
Topic
Horses--Physiology
Subject (authority = ETD-LCSH)
Topic
Homeostasis
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_5703
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xi, 141 p. : ill.)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Ryan Charles Avenatti
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3FJ2F8C
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Avenatti
GivenName
Ryan
MiddleName
Charles
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2014-06-04 09:28:48
AssociatedEntity
Name
Ryan Avenatti
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2014-10-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2016-10-30
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after October 30th, 2016.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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