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The bacteriocin subtilosin A and synergistically acting conventional antimicrobials for control of bacterial vaginosis-associated pathogens

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TitleInfo
Title
The bacteriocin subtilosin A and synergistically acting conventional antimicrobials for control of bacterial vaginosis-associated pathogens
Name (type = personal)
NamePart (type = family)
Cavera
NamePart (type = given)
Veronica L.
NamePart (type = date)
1989-
DisplayForm
Veronica L. Cavera
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Chikindas
NamePart (type = given)
Michael L.
DisplayForm
Michael L. Chikindas
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Boyd
NamePart (type = given)
Jeff
DisplayForm
Jeff Boyd
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Matthews
NamePart (type = given)
Karl
DisplayForm
Karl Matthews
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2014
DateOther (qualifier = exact); (type = degree)
2014-10
CopyrightDate (encoding = w3cdtf)
2014
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Bacterial vaginosis is one of the most prevalent vaginal infections in women of child-bearing age and is caused by the shift of healthy lactobacilli to anaerobic pathogenic bacteria including Gardnerella vaginalis. While current antibiotic treatments were initially effective there is increasing evidence of resistance as well as damage to normal flora. The papers herein address the usage of bacteriocins for the purpose of indicating methods of more efficiently inhibiting G. vaginalis while having little effect on normal flora. (i) is a review on the current landscape of antibiotics and posits that bacteriocins present a viable option as either synergists to current antibiotics or as potential next generation option. (ii) is a research paper on the interaction of four antimicrobials (lauramide arginine, ε-poly-L-lysine, clindamycin phosphate and metronidazole) and subtilosin against G. vaginalis and four clinical isolates of lactobacilli. The combinations of CS and MS were synergistic in terms of FICI while all tested combinations displayed Bliss synergy against G. vaginalis. (iii) is a research paper in which a polyethylene glycol (PEG) gel with passively entrapped subtilosin was shown to cause a 8 log10 CFU/ml reduction of G. vaginalis with quantities < 15 μg/mL of subtilosin in a bimodal release kinetic in OD595 endpoint experiments. No inhibition of lactobacilli spp. was observed. Rheological properties were also recorded, indicating the gel is appropriate for vaginal application. (iv) is a polycarbophil Carbopol® 934P hydrogel which encapsulates benzoyl peroxide capable of inhibiting G. vaginalis but not normal vaginal lactobacilli. Gels with 0.01% v/v of BPO inhibited G. vaginalis while gels with 2.5% v/v of BPO inhibited tested lactobacilli in direct contact time kill assays and well diffusion assays. Rheological tests indicated that the gel was ideal for human usage and that the addition of BPO did not alter its physiochemical properties. (v) is a review that discusses bacteriocins and their usage in delivery systems. Each paper is linked through the ideas that of bacteriocins (i, ii, iii, v), bacteriocins and BV (ii, iii), BV (ii, iii, iv) or drug delivery systems (ii, iii, iv, v).
Subject (authority = RUETD)
Topic
Microbial Biology
Subject (authority = ETD-LCSH)
Topic
Vaginitis--microbiology
Subject (authority = ETD-LCSH)
Topic
Bacteriocins
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_5725
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (vii, 158 p. : ill.)
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Veronica L. Cavera
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3251GN4
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Cavera
GivenName
Veronica
MiddleName
L.
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2014-07-02 13:52:24
AssociatedEntity
Name
Veronica Cavera
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2014-10-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2015-05-02
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after May 2nd, 2015.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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