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Fabrication of surface enhanced raman scattering substrates by controlled assembly and morphology tuning of gold nanoparticles

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Name (type = personal)
NamePart (type = family)
De Silva Indrasekara
NamePart (type = given)
Agampodi Swarnapali
NamePart (type = date)
1983-
DisplayForm
Agampodi Swarnapali De Silva Indrasekara
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Fabris
NamePart (type = given)
Laura
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Laura Fabris
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Moghe
NamePart (type = given)
Prabhas V
DisplayForm
Prabhas V Moghe
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Mann
NamePart (type = given)
Adrian B
DisplayForm
Adrian B Mann
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Arslanoglu
NamePart (type = given)
Julie-Anne M
DisplayForm
Julie-Anne M Arslanoglu
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2014
DateOther (qualifier = exact); (type = degree)
2014-10
CopyrightDate (encoding = w3cdtf)
2014
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
The design and fabrication of nanoparticles (NPs) and NP assemblies to sustain intense electromagnetic field enhancement for surface enhanced Raman scattering (SERS)-based imaging and sensing have recently gained significant attention. In SERS, the intrinsic optical properties of plasmonic NPs are used to overcome the relatively low Raman cross-sections and thereby increase sensitivity. Sharp features in anisotropic NPs and interparticle gaps within NP assemblies have been identified as the locations where the highest SERS enhancements can be achieved, also known as “hot spots”. Many attempts have been reported that deal with the bottom-up assembly of NPs to achieve highly reproducible, sensitive, and well characterized SERS substrates, but it still remains a challenge to attain monodisperse, highly reproducible “hot spots” and directional assembly. The focus of this dissertation is to develop synthetic protocols for controlled engineering of NPs with SERS “hot spots”, and thereby to contribute to the advancement of SERS-based sensing and imaging applications. In this dissertation, the development of SERS substrates has evolved from dimers of spherical gold NPs (SP), to star-shaped gold NPs (ST), and finally to assembled superstructures of ST and SPs. The kinetically controlled assembly of SPs into dimers was achieved by using Raman active dithiolated linker molecules, with the highest yield reported for this method to the best of our knowledge, leading to SERS tags with a reproducible SERS enhancement on the order of 105. NP dimers, surface-functionalized to target U87 glioblastoma cancer cells, demonstrated a fast, reliable, and selective SERS-based detection of the diseased cells that outperforms fluorescence. The morphology of the STs was modified to possess longer and sharper spikes with a narrower tip curvature thereby increasing the electromagnetic field localization at the tips. SERS substrates were designed by periodically and reproducibly immobilizing STs on a planar substrate with high surface coverage and limited to no clustering, thus enabling femtomolar detection of organic analytes with an outstanding 109 SERS enhancement. Finally, the core-satellite assemblies of ST with SPs were achieved through conjugation linker chemistry. These assemblies demonstrated SERS enhancement of two orders of magnitudes greater than isolated STs thereby improving the sensitivity of potential SERS-based imaging and sensing applications.
Subject (authority = RUETD)
Topic
Materials Science and Engineering
Subject (authority = ETD-LCSH)
Topic
Raman spectroscopy
Subject (authority = ETD-LCSH)
Topic
Surface chemistry
Subject (authority = ETD-LCSH)
Topic
Nanoparticles
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_5720
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
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text/xml
Extent
1 online resource (xv, 142 p. : ill.)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Agampodi Swarnapali De Silva Indrasekara
TitleInfo
Title
Fabrication of surface enhanced raman scattering substrates by controlled assembly and morphology tuning of gold nanoparticles
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
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NjNbRU
Identifier (type = doi)
doi:10.7282/T37P8WWM
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
De Silva Indrasekara
GivenName
Agampodi Swarnapali
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2014-06-25 17:47:42
AssociatedEntity
Name
Agampodi Swarnapali De Silva Indrasekara
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2014-10-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2015-10-31
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after October 31st, 2015.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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ETD
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windows xp
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