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Loss-in-weight feeding in continuous powder manufacturing
Descriptive
TitleInfo
Title
Loss-in-weight feeding in continuous powder manufacturing
Name
(type = personal)
NamePart
(type = family)
Engisch
NamePart
(type = given)
William E.
DisplayForm
William E. Engisch, Jr.
Role
RoleTerm
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author
NamePart
(type = termsOfAddress)
Jr.
Name
(type = personal)
NamePart
(type = family)
Muzzio
NamePart
(type = given)
Fernando J
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Fernando J Muzzio
Affiliation
Advisory Committee
Role
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(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Ierapetritou
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(type = given)
Marianthi
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Marianthi Ierapetritou
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Ramachandran
NamePart
(type = given)
Rohit
DisplayForm
Rohit Ramachandran
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Kiang
NamePart
(type = given)
San
DisplayForm
San Kiang
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2014
DateOther
(qualifier = exact);
(type = degree)
2014-10
CopyrightDate
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2014
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Processes involving granular material handling are found in many industries, such as pharmaceutical, chemical, catalyst, and food. Significant differences are observed, both between materials as well as between handling methods. Often, special equipment has been developed to monitor, control, and feed these widely varied materials in order to enable the end user to continuously feed or dose the raw powder material so that it can be continuously processed, which has many advantages over batch processing. To address the difficulties of feeding granular materials, powder feeders are equipped with a variety of tooling that can be used for various rates and powders. Unfortunately most of the sizing and performance knowledge is internal to the feeding equipment manufacturers and is not generally available to the end-user. In this work, a method for evaluating feeding performance was developed, which allowed for testing that was independent of the type of feeder being evaluated. This method was applied to various feeders to characterize the feeders for the feeding of various powders. In addition, the effects of hopper refilling were quantified and investigated. Finally, the downstream effects were simulated. iii For each powder, the fluctuations caused during normal steady state feeding were minimized through tooling and feeder selection. The effects of refill were found to be considerably more significant than the fluctuations associated with steady state feeding. However, optimized refill schedules, easily reduced the deviations to more manageable levels. In continuous manufacturing systems, the feeders are a potential high risk to content uniformity. The implications of this are investigated from a overarching view of a pharmaceutical direct compression system with a specific focus on regulatory compliance and product quality. Regulatory compliance requires batch definition and raw material traceability, and solutions to both were investigated. The presented options for batch definition are based on the residence time distribution (RTD) of the system, which describes the dispersion of material across the interface between "batches". Raw material traceability was similarly investigated utilizing residence time distribution as a tool.
Subject
(authority = RUETD)
Topic
Chemical and Biochemical Engineering
Subject
(authority = ETD-LCSH)
Topic
Granular materials
Subject
(authority = ETD-LCSH)
Topic
Manufacturing processes
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_5933
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xix, 259 p. : ill.)
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by William E. Engisch, Jr.
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
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rucore19991600001
Location
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(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T31Z42VM
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Engisch
GivenName
William
MiddleName
E.
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2014-09-29 00:29:46
AssociatedEntity
Name
William Engisch
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
(ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem
(VERSION = 5.1)
windows xp
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