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Size and shape-based separation using deterministic lateral displacement microfludic systems

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TitleInfo
Title
Size and shape-based separation using deterministic lateral displacement microfludic systems
Name (type = personal)
NamePart (type = family)
Jiang
NamePart (type = given)
Mingliang
NamePart (type = date)
1990-
DisplayForm
Mingliang Jiang
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Drazer
NamePart (type = given)
German
DisplayForm
German Drazer
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Shojaei-Zadeh
NamePart (type = given)
Shahab
DisplayForm
Shahab Shojaei-Zadeh
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Mazzeo
NamePart (type = given)
Aaron
DisplayForm
Aaron Mazzeo
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2014
DateOther (qualifier = exact); (type = degree)
2014-10
CopyrightDate (encoding = w3cdtf)
2014
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Continuous separation of particles of different sizes and shapes is important in both clinical diagnostics and industrial applications and a number of methods have been developed for such separations. In microfluidic systems, deterministic lateral displacement has proved its great potential in achieving the goal of high throughput and efficient separation. Although it was originally based on transporting the suspension in a convective flow, particles can be also driven with external force fields, thus force-driven DLD (f-DLD) devices were demonstrated. This thesis demonstrates the separation of suspended particles by shape and size using scaled-up macroscopic f-DLD devices, using gravity force and a centrifuge, respectively. In the first set of experiments and for the first time, we demonstrate the potential of gravity-driven DLD devices for the separation of particles of different shapes. Our results show that each type of particle moves in different directions within the array of obstacles in DLD systems, depending on the forcing direction. Interestingly, we show that the migration of the particles can be predicted by the diameter of the inscribed sphere, independent of shape. In the second set of experiments and also for the first time, we combined DLD devices with centrifugal force as the driving field. We show that spherical particles of different sizes are driven to different outlets. We show that at some specific angles this setup provides high separation resolution, but the resolution decreases as the concentration of particles increases.
Subject (authority = RUETD)
Topic
Mechanical and Aerospace Engineering
Subject (authority = ETD-LCSH)
Topic
Microfluidics
Subject (authority = ETD-LCSH)
Topic
Particles--Fluid dynamics
Subject (authority = ETD-LCSH)
Topic
Centrifugal force
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Identifier
ETD_5980
Identifier (type = doi)
doi:10.7282/T35D8Q9J
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (ix, 38 p. : ill.)
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Mingliang Jiang
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Note (type = funding)
This work was partially supported by the National Science Foundation Grant no. CBET-1339087.
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Science Foundation
AssociatedObject
Type
Grant number
Name
CBET-1339087
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Jiang
GivenName
Mingliang
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2014-09-30 23:22:16
AssociatedEntity
Name
Mingliang Jiang
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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