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Genetic and environmental modulation of necrosis and health span in Caenorhabditis elegans

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TitleInfo
Title
Genetic and environmental modulation of necrosis and health span in Caenorhabditis elegans
Name (type = personal)
NamePart (type = family)
Kamat
NamePart (type = given)
Shaunak
NamePart (type = date)
1981-
DisplayForm
Shaunak Kamat
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Grant
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Barth
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Barth Grant
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Barr
NamePart (type = given)
Maureen
DisplayForm
Maureen Barr
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Padgett
NamePart (type = given)
Richard
DisplayForm
Richard Padgett
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2014
DateOther (qualifier = exact); (type = degree)
2014-10
CopyrightDate (encoding = w3cdtf)
2014
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Living systems rely on tightly regulated gene expression networks in order to maintain a stable internal milieu, a process known as homeostasis, and to interact with their environment. The study of regulatory networks involved in key processes such as energy metabolism and cellular responses to hostile environmental conditions has immense therapeutic potential and is the focus of a large and growing body of research. This dissertation describes two processes – neuronal necrosis, and the metabolic effects of the phytoecdysteroid 20-hydroxyecdysone in the invertebrate model system C. elegans, with a focus on the underlying molecular mechanisms and their potential therapeutic value. The first part of this dissertation deals with the cellular response to necrosis, a catastrophic event caused by extreme departure from homeostatic conditions due to exposure to toxic chemicals, extreme temperature or mechanical trauma. Using genetically encoded hyperactive DEG/ENaC ion channels as inducers of necrosis, I describe the role of ER chaperone NRA-2 in the modulation of necrosis caused by calcium excitotoxicity and suggest a broader role for ER chaperones in the regulation of channel expression, with potential therapeutic value in the treatment of disease pathology caused by malformed DEG/ENaC channels. The second part of this dissertation deals with the effects of the plant-derived steroid hormone 20-hydroxyecdysone (20HE) that extends C. elegans health span and modulates energy metabolism. I describe the effects of this compound on conserved metabolic pathways and suggest a potential mechanism of action. This study highlights the conservation of gene networks governing nutrient metabolism and the importance of C. elegans as a model system in identifying therapeutic targets for the treatment of metabolic syndrome. In sum, the dissertation describes two unrelated processes in C. elegans with the common theme being a conserved genetically encoded regulatory network and its interaction with a specific environmental cue.
Subject (authority = RUETD)
Topic
Neuroscience
Subject (authority = ETD-LCSH)
Topic
Caenorhabditis elegans--Genetics
Subject (authority = ETD-LCSH)
Topic
Neurons--Physiology
Subject (authority = ETD-LCSH)
Topic
Necrosis
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_5522
PhysicalDescription
Form (authority = gmd)
electronic resource
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application/pdf
InternetMediaType
text/xml
Extent
1 online resource (vii, 102 p. : ill.)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Shaunak Kamat
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T31N7ZKT
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Kamat
GivenName
Shaunak
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2014-04-15 14:31:15
AssociatedEntity
Name
Shaunak Kamat
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2014-10-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2015-10-31
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after October 31st, 2015.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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