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Application of emulsion-based delivery system to enhance bioavailability and efficacy of tangeretin

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TitleInfo
Title
Application of emulsion-based delivery system to enhance bioavailability and efficacy of tangeretin
Name (type = personal)
NamePart (type = family)
Ting
NamePart (type = given)
Yuwen
NamePart (type = date)
1985-
DisplayForm
Yuwen Ting
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
HUANG
NamePart (type = given)
QINGRONG
DisplayForm
QINGRONG HUANG
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
HO
NamePart (type = given)
CHI-TANG
DisplayForm
CHI-TANG HO
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Lee
NamePart (type = given)
Tung-Ching
DisplayForm
Tung-Ching Lee
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
HUANG
NamePart (type = given)
MOU-TUAN
DisplayForm
MOU-TUAN HUANG
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2014
DateOther (qualifier = exact); (type = degree)
2014-10
CopyrightDate (encoding = w3cdtf)
2014
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Tangeretin (5,6,7,8,4′-pentamethoxyflavone) is a polymethoxylated flavone found predominantly in citrus fruit peels. Numerous bio-functionalities have previously been reported for tangeretin. For chronic intakes, oral ingestion is typically the preferred method since it is the most convenient and non-invasive application route. However, tangeretin exhibits poor oral bioavailability as a result of its hydrophobic chemical structure. Consequently, the required tangeretin oral dosage for many intended therapeutic purposes is difficult to achieve. In this work, we aim to use an emulsion-based delivery system to enhance the bioavailability and efficacy of tangeretin. In first part of this work, a viscoelastic emulsion system containing >2.5% tangeretin was developed and its physical properties were characterized. In this viscoelastic emulsion system, the emulsion-encapsulated tangeretin was mixed with homogeneously-entrapped tangeretin crystals, which exhibited remarkable storage stability over six months. Following the development of the tangeretin emulsion system, the processing parameters were further optimized to obtain the required properties that may best enhance the oral bioavailability and efficacy. The ability of an emulsion-based delivery system to improve the oral bioavailability of tangeretin was examined using in vitro and in vivo models. In vitro lipolysis and TNO gastrointestinal model revealed that emulsion-delivered tangeretin was digested considerably more quickly and was 2.6-fold more bioaccessible than unformulated medium-chain triglyceride (MCT) suspension. In vivo pharmacokinetics analysis on mice confirmed that the oral bioavailability of tangeretin in the emulsion-based system was increased 2.3-fold, with a 23% increase in Cmax when compared with the unformulated suspension. Moreover, the emulsion-based delivery was proven to be an effective method to increase the oral therapeutic efficacy of tangeretin. The in vitro anti-proliferative activity of tangeretin was first evaluated using MTT essay on colonic carcinoma cell lines and was significantly improved by the use of the emulsion delivery system. The effectiveness of the emulsion system to enhance the in vivo oral efficacy of tangeretin against colorectal cancer development was also evaluated by the AOM/DSS-induced colitis-related colon tumorigenesis model. The tumor incidence, multiplicity, and pathological signs of colorectal adenoma were significantly reduced when tangeretin emulsion was applied. Finally, the related toxicity effects of the tangeretin viscoelastic emulsion were also investigated.
Subject (authority = RUETD)
Topic
Food Science
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_6007
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xxiv, 229 p. : ill.)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Subject (authority = ETD-LCSH)
Topic
Drug delivery systems
Subject (authority = ETD-LCSH)
Topic
Flavonoids
Note (type = statement of responsibility)
by Yuwen Ting
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T30V8FC2
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Ting
GivenName
Yuwen
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2014-10-08 13:40:19
AssociatedEntity
Name
Yuwen Ting
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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