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Inspiratory muscle strength in adults with stable cystic fibrosis
Descriptive
TitleInfo
Title
Inspiratory muscle strength in adults with stable cystic fibrosis
SubTitle
clinical predictors and the influence of disease severity
Name
(type = personal)
NamePart
(type = family)
Dekerlegand
NamePart
(type = given)
Robert
NamePart
(type = date)
1970-
DisplayForm
Robert Dekerlegand
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Myslinski
NamePart
(type = given)
Mary Jane
DisplayForm
Mary Jane Myslinski
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Parrott
NamePart
(type = given)
James Scott
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James Scott Parrott
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Heuer
NamePart
(type = given)
Al
DisplayForm
Al Heuer
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Swisher
NamePart
(type = given)
Anne K
DisplayForm
Anne K Swisher
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
School of Health Related Professions
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2014
DateOther
(qualifier = exact);
(type = degree)
2014-10
CopyrightDate
(encoding = w3cdtf)
2014
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Introduction: The work of breathing (WOB) imposed on the inspiratory muscles (IM) is elevated in cystic fibrosis (CF). Impaired inspiratory muscle strength (IMS) may contribute to dyspnea and exercise intolerance. Literature favors the preservation of (IMS) in adults with CF; however, this may misrepresent IM involvement due to the heterogeneity of study participants. Impaired IMS cannot be fully ruled out as the influence of disease severity has not been investigated. Clinical predictors of IMS in adults with CF are needed to identify individuals at risk for inspiratory overload. Purpose: The purpose of this study was to investigate the influence of disease severity on IMS and determine the potential for clinical measures to predict IMS in adults with stable CF. Methods: Maximal inspiratory pressure expressed in cmH2O (MIP) and percent of predicted (%MIP) was assessed to represent IMS in a cross-sectional sample of adults with stable CF. Between-group differences in MIP and %MIP were analyzed in adults with CF stratified by disease severity in comparison to healthy controls through general linear modelling. The ability for clinical measures to predict IMS was investigated through regression analysis. Results: Fifty-eight adults with CF and 20 healthy controls completed the study. IMS was decreased in advanced pulmonary disease. Dyspnea was associated with MIP (r=-0.48, p<0.001) and %MIP (r=-0.50, p<0.001). Disease severity accounted for 23% of the variance seen in MIP and %MIP after controlling for confounding variables (p<0.001). Resultant linear models explained 43% of the variance in MIP and 52% in %MIP. Conclusions: Disease severity negatively influences IMS in adults with CF and impaired IMS can be missed when not controlling for the degree of airway obstruction. Decreased IMS is apparent in the presence of advanced CF-related lung disease though select individuals may be protected against this impairment. A combination of pulmonary, nutritional, and demographic factors may identify adults with CF at risk for inspiratory overload in need of IM testing. The clinical significance of these findings should be determined through prospective studies. Future research on the IM in CF must control for disease severity or risk misrepresenting the influence of CF lung disease.
Subject
(authority = RUETD)
Topic
Health Sciences
Subject
(authority = ETD-LCSH)
Topic
Cystic fibrosis--Patients
Subject
(authority = ETD-LCSH)
Topic
Muscle strength
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_5751
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (239 p. : ill.)
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Robert L. Dekerlegand PT, MPT, CCS
RelatedItem
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TitleInfo
Title
School of Health Related Professions ETD Collection
Identifier
(type = local)
rucore10007400001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3Z89F1S
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Dekerlegand
GivenName
Robert
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2014-08-01 13:23:15
AssociatedEntity
Name
Robert Dekerlegand
Role
Copyright holder
Affiliation
Rutgers University. School of Health Related Professions
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2014-10-31
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = end)
2016-10-30
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after October 30th, 2016.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
(ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem
(VERSION = 5.1)
windows xp
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Statistical Profile