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A calibrated agent-based computer model of stochastic cell dynamics in normal human colon crypts useful for in silico experiments

Descriptive

TypeOfResource
Text
TitleInfo
Title
A calibrated agent-based computer model of stochastic cell dynamics in normal human colon crypts useful for in silico experiments
Name (type = personal)
NamePart (type = family)
Bravo
NamePart (type = given)
Rafael
Affiliation
Computer Science (New Brunswick), Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Axelrod
NamePart (type = given)
David E.
Affiliation
Genetics, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Genetics
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
School of Arts and Sciences (SAS) (New Brunswick)
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Version of Record (VoR)
Genre (authority = ExL-Esploro)
Journal Article
OriginInfo
DateCreated (encoding = w3cdtf); (keyDate = yes); (qualifier = exact)
2013
Publisher
BioMed Central
Abstract (type = Abstract)
A virtual crypt has been developed that simulates the quasi-stationary stochastic cell dynamics of normal human colon crypts. It is unique in that it has been calibrated with measurements of human biopsy specimens, and it can simulate the variation of cell types in addition to the average number of each cell type. The utility of the model was demonstrated with in silico experiments that evaluated cancer therapy protocols. The model is available for others to conduct additional experiments.
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
24 p.
Subject (authority = local)
Topic
Agent-based model
Subject (authority = LCSH)
Topic
Multiagent systems
Subject (authority = local)
Topic
Colon crypt
Subject (authority = local)
Topic
Cell dynamics
Subject (authority = LCSH)
Topic
Stem cells
Subject (authority = LCSH)
Topic
Adenoma
Subject (authority = local)
Topic
Colon cancer
Subject (authority = LCSH)
Topic
Colon (Anatomy)--Cancer
Subject (authority = LCSH)
Topic
Chemotherapy
Subject (authority = local)
Topic
Radiation therapy
Subject (authority = LCSH)
Topic
Radiotherapy
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2013
AssociatedObject
Name
Theoretical Biology and Medical Modelling
Type
Journal
Relationship
Has part
Detail
66-89
Identifier (type = volume and issue)
10(66)
Reference (type = url)
http://dx.doi.org/10.1186/1742-4682-10-66
RelatedItem (type = host)
TitleInfo
Title
Axelrod David Collection
Identifier (type = local)
rucore30017800001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T39G5PFQ
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Rights

RightsHolder (type = personal)
Name
FamilyName
Bravo
GivenName
Rafael
Role
Copyright holder
RightsHolder (type = personal)
Name
FamilyName
Axelrod
GivenName
David
MiddleName
E.
Role
Copyright holder
RightsDeclaration (AUTHORITY = FS); (ID = rulibRdec0004)
Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers.Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work.I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others.I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work.By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
Document
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