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Biofunctionalization and surface studies of semiconductor materials for sensing device fabrication

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TitleInfo
Title
Biofunctionalization and surface studies of semiconductor materials for sensing device fabrication
Name (type = personal)
NamePart (type = family)
Cao
NamePart (type = given)
Yan
NamePart (type = date)
1984-
DisplayForm
Yan Cao
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Galoppini
NamePart (type = given)
Elena
DisplayForm
Elena Galoppini
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Mendelsohn
NamePart (type = given)
Richard
DisplayForm
Richard Mendelsohn
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
He
NamePart (type = given)
Huixin
DisplayForm
Huixin He
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Lu
NamePart (type = given)
Yicheng
DisplayForm
Yicheng Lu
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - Newark
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (encoding = w3cdtf); (qualifier = exact)
2014
DateOther (qualifier = exact); (type = degree)
2015-01
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2014
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract
This thesis describes the development and study of innovative approaches for stepwise functionalization of semiconductor surfaces. The methods developed in this thesis were applied to improve the selectivity and sensitivity of sensor devices. The research projects involved in this thesis encompass material synthesis, biochemical functionalization, interfacial analysis, and nano-device development. Inorganic semiconductor-based sensor devices, including ZnO and MgZnO nanostructured surfaces, and organic semiconductor (rubrene single crystals) were involved in these studies. 1) For inorganic nanomaterial-based sensor devices, we studied the effect of the surface morphology on the capabilities of the nano-sensors. The surfaces studied were inorganic ZnO nano-structured semiconductors of three morphologies: nanorod, rough, and planar. These morphology effect studies were carried out by functionalization of ZnO surfaces with a linker possessing a terminal alkylthiol for coupling to single-stranded DNA. The resulting ssDNA-functionalized films were then hybridized with complementary ssDNA tagged with fluorescein. In a selectivity control experiment, no hybridization occurred upon treatment with non-complementary DNA. The ZnO films’ surface functionalization, characterized by FT-IR-ATR and fluorescence spectroscopy and detected on the nano-QCM, was successful on nanorod and rough surfaces but was barely detectable on the planar surface. The copper-free click reaction was successfully explored as a surface functionalization methodology for ZnO and MgZnO nanorod films. 11-Azidodecanoic acid was bound to ZnO and MgZnO nanorod films through the carboxylic acid moiety, leaving an azide group available for Cu-free click reaction with alkynes. The azide-functionalized layer was used to immobilize various molecules, either a fluorescent probe, for example pyrene, or a small bioactive molecule, for example biotin or folic acid, capped with an alkyne. The immobilization of pyrene on the surface was probed by fluorescence spectroscopy, and immobilization of biotin was confirmed by binding with streptavidin-fluorescein isothiocyanate. The functionalization of ZnO and MgZnO films was monitored by FT-IR-ATR, steady-state fluorescence emission, fluorescence microscopy, and FESEM. Additionally, in a side development of the step-wise functionalization of inorganic semiconductor surfaces, this thesis proposed a pyrene-cucurbit[8]uril host-guest system to control binding orientation on nanostructured ZrO2 and TiO2 semiconductor surfaces. The fluorescence emission spectra were mainly used to study the binding orientation on surfaces. With encapsulation of pyrene-based chromphore into CB8 to form a guest@host complex, the sharp blue-shifted monomer peak was presented in emission spectra and it helped to suppress the formation of excimer. 2) For organic semiconductor material, rubrene single crystal surface was functionalized with a trichlorosilane or diazonium salt as an anchor group, leaving an azide functional group for further Click Chemistry to immobilize various molecules. The modification to the rubrene surface was monitored by conductivity changes and Hall measurements.
Subject (authority = RUETD)
Topic
Chemistry
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_6097
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xxi, 183 p. : ill.)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = vita)
Includes vita
Subject (authority = ETD-LCSH)
Topic
Semiconductors--Surfaces
Subject (authority = ETD-LCSH)
Topic
Detectors
Subject (authority = ETD-LCSH)
Topic
Semiconductors--Materials
Note (type = statement of responsibility)
by Yan Cao
RelatedItem (type = host)
TitleInfo
Title
Graduate School - Newark Electronic Theses and Dissertations
Identifier (type = local)
rucore10002600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3SB47GC
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Cao
GivenName
Yan
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2014-12-28 20:48:34
AssociatedEntity
Name
Yan Cao
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - Newark
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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