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Neural oscillations arising from a linear current with negative conductance

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TitleInfo
Title
Neural oscillations arising from a linear current with negative conductance
Name (type = personal)
NamePart (type = family)
Guan
NamePart (type = given)
Yinzheng
NamePart (type = date)
1985-
DisplayForm
Yinzheng Guan
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Bonder
NamePart (type = given)
Edward
DisplayForm
Edward Bonder
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Nadim
NamePart (type = given)
Farzan
DisplayForm
Farzan Nadim
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Golowasch
NamePart (type = given)
Jorge
DisplayForm
Jorge Golowasch
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Tran
NamePart (type = given)
Tracy
DisplayForm
Tracy Tran
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - Newark
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (encoding = w3cdtf); (qualifier = exact)
2015
DateOther (qualifier = exact); (type = degree)
2015-01
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2015
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Slow oscillations underlying neuronal bursting commonly involve a regenerative inward ionic current with a nonlinear inverted bell-shape IV curve. In the crab pyloric central pattern generator (CPGs), multiple peptidergic modulatory inputs activate the regenerative inward current IMI in several pyloric neurons, which is critical for the generation of neuronal oscillations. Our recent work suggests that the contribution of such regenerative currents to the production of oscillations is limited to the region of the IV curve in which the current exhibits a linear negative-slope conductance (INL). When INL is introduced with dynamic clamp in the pyloric pacemaker PD neurons, it can recover oscillations, even when the neuron is isolated by TTX(Bose, Golowasch, Guan, & Nadim, 2014) . However, it is unknown whether other pyloric neurons can produce oscillations in the presence of INL and, if not, what factors determine the ability of INL to produce them. We examined whether, in the presence of TTX, INL is sufficient for producing slow oscillations in synaptically-isolated pyloric neurons. We found that the pyloric dilator PD neuron can produce INL-induced oscillations in a range of gNL (40-300 nS) and ENL (-15 to +15 rel. to Erest) values. The oscillation cycle period and amplitude decline with |gNL| and ENL. In contrast to the pyloric dilator (PD) neuron, even when gNL and ENL were varied in a large range, none of the follower pyloric neuron types pyloric constrictor (PY) (0/6), lateral pyloric (LP) (1/8), inferior cardiac (IC) (0/3), ventral dilator (VD) (0/3), lateral posterior gastric (LPG) (0/3) could produce slow oscillations with INL. We explored what factors may oppose the expression of oscillations in LP neurons in the presence of INL. Our previous modeling work suggests that INL-induced oscillations depend on a balance between INL and the voltage-gated outward currents (Bose et al., 2014). We therefore compared the outward currents in the PD and LP, PD and VD neurons. We found that the LP and VD neurons has a significantly larger high-threshold K current (IHTK: delayed rectifier and Ca2+-dep. K+ currents) than PD (20% larger at 0 mV), and that PD has a larger IA than LP (45% larger at 0 mV). We thus examined whether changing the levels of IHTK and IA would affect the ability of PD or LP and VD to oscillate with INL. We found that LP and VD can oscillate with INL by reducing IHTK using TEA (N=4). However, in the presence of the 4AP we find that IA does not contribute to PD oscillation in INL (N=3). We conclude that interaction of INL with a slow voltage-gated outward current, is potentially leading to the generation of neuronal oscillations: these neurons are tuned to express their currents levels in a way that fit in such an oscillatory range if they have the oscillatory properties. This study has very important scientific value because it: 1. Contribute to understanding the role that leak currents –INL play in the transition from non-oscillatory to oscillatory activity. 2. Allows us to assess and define the intrinsic properties of different pyloric neurons. 3. Helps us to understand how a linear leak current INL can mimic a nonlinear regenerative current IMI to recover oscillatory activity.
Subject (authority = RUETD)
Topic
Biology
Subject (authority = ETD-LCSH)
Topic
Neurons--Physiology
Subject (authority = ETD-LCSH)
Topic
Synapses--Physiology
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_6183
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xi, 43 p. : ill.)
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = vita)
Includes vita
Note (type = statement of responsibility)
by Yinzheng Guan
RelatedItem (type = host)
TitleInfo
Title
Graduate School - Newark Electronic Theses and Dissertations
Identifier (type = local)
rucore10002600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3D50PNB
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Guan
GivenName
Yinzheng
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2015-01-14 00:53:53
AssociatedEntity
Name
Yinzheng Guan
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - Newark
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License
Name
Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
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Copyright protected
Availability
Status
Open
Reason
Permission or license
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RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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