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Mechanistic modeling, simulation and optimization of wet granulation processes
Descriptive
TitleInfo
Title
Mechanistic modeling, simulation and optimization of wet granulation processes
Name
(type = personal)
NamePart
(type = family)
Chaudhury
NamePart
(type = given)
Anwesha
DisplayForm
Anwesha Chaudhury
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Ramachandran
NamePart
(type = given)
Rohit
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Rohit Ramachandran
Affiliation
Advisory Committee
Role
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(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Ierapetritou
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Marianthi
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Marianthi Ierapetritou
Affiliation
Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Shapley
NamePart
(type = given)
Nina
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Nina Shapley
Affiliation
Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Dutt
NamePart
(type = given)
Meenakshi
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Meenakshi Dutt
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Pandey
NamePart
(type = given)
Preetanshu
DisplayForm
Preetanshu Pandey
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
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NamePart
Graduate School - New Brunswick
Role
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school
TypeOfResource
Text
Genre
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theses
OriginInfo
DateCreated
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(qualifier = exact)
2015
DateOther
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(type = degree)
2015-01
CopyrightDate
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(qualifier = exact)
2015
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
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(type = code)
eng
Abstract
(type = abstract)
Particulate processes involving handling of solids are ubiquitous in various industries and are typically operated inefficiently due to a lack of adequate mechanistic process understanding. A primary application of such processes is found in the pharmaceutical industry that involve manufacturing of solid dosage forms (e.g. tablets). Granulation is a critical particulate process that plays an important role in the overall manufacture of pharmaceutical drugs. This work focuses on improved mathematical modeling of granulation processes using the population balance framework. One of the primary objectives deals with model development for granulation followed by development of improved numerical techniques for reduced computational overheads associated with the solution techniques for solving population balance models. This study is also aimed at identifying the influence of various operating parameters on the final granule properties through the development of a novel semi-mechanistic kernel and an integrated mesoscale model framework that can effectively capture key granulation dynamics. A compartmentalized model has also been formulated for a high-shear wet granulator that can capture the inhomogeneities (with respect to liquid and particle velocity) within the vessel. This integrated, compartment-based model can be further extended for open loop optimization and control of the granulation process, which can aid at obtaining an optimal recipe for the operation of the granulation process. This work will make a significant contribution towards improved understanding of the granulation process and is aimed at mitigating the current inefficient operation of the process.
Subject
(authority = RUETD)
Topic
Chemical and Biochemical Engineering
Subject
(authority = ETD-LCSH)
Topic
Granular materials
Subject
(authority = ETD-LCSH)
Topic
Wetting
Subject
(authority = ETD-LCSH)
Topic
Granulation
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_6053
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xiv, 152 p. : ill.)
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Anwesha Chaudhury
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
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rucore19991600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3NC62WJ
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Chaudhury
GivenName
Anwesha
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2014-12-14 17:03:16
AssociatedEntity
Name
Anwesha Chaudhury
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
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ContentModel
ETD
OperatingSystem
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windows xp
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