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Phytochemicals for prostate cancer prevention
Descriptive
TitleInfo
Title
Phytochemicals for prostate cancer prevention
SubTitle
integrating redox signaling, epigenetics and genetics in vitro and in vivo
Name
(type = personal)
NamePart
(type = family)
Huang
NamePart
(type = given)
Ying
NamePart
(type = date)
1986-
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Ying Huang
Role
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(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Kong
NamePart
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Ah-Ng Tony
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Ah-Ng Tony Kong
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Advisory Committee
Role
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chair
Name
(type = personal)
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Kagan
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Leonid
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Leonid Kagan
Affiliation
Advisory Committee
Role
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(authority = RULIB)
internal member
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(type = personal)
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(type = family)
Minden
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(type = given)
Audre
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Audre Minden
Affiliation
Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Cai
NamePart
(type = given)
Li
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Li Cai
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
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NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
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NamePart
Graduate School - New Brunswick
Role
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(authority = RULIB)
school
TypeOfResource
Text
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theses
OriginInfo
DateCreated
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2015
DateOther
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2015-01
CopyrightDate
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2015
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Prostate cancer is the most prevalent type of non-skin cancer among men in the United States. The development of prostate cancer generally consists of three stages—initiation, promotion and progression. Many phytochemical display preventive effects against prostate cancer by blocking the tumor initiation and/or suppressing the promotion and progression. Nrf2 is a master regulator of the antioxidant response and xenobiotic metabolism through the regulation of a wide range of antioxidant and phase II detoxification genes. Nrf2 protects cells from stressors, including endogenous substances, reactive oxygen species, radiation, environmental toxins, and xenobiotics from food. The protective role of Nrf2 points its potential importance in prostate carcinogenesis. Coincidentally, our group has reported that as prostate progresses in the transgenic adenocarcinoma of mouse prostate (TRAMP) model, there is a progressive loss of expression of Nrf2 and its downstream target genes, which is associated CpG hypermethylation in the promoter region. Curcumin (CUR), tocopherols (T) and tocotrienols (T3) were found to be powerful cancer chemopreventive agents using animal models of different cancers including prostate cancer. Using TRAMP C1 cells, we demonstrated that CUR is a potent demethylation agent and it restores the epigenetically silenced Nrf2 gene through DNA demethylation. In addition, we showed that a γ-tocopherol-rich mixture of tocopherols (γTmT) treatment reduced the incidence of palpable tumor incidence in TRAMP mice. γTmT also inhibited the CpG hypermethylation in the Nrf2 promoter during prostate cancer progression and maintained Nrf2 and its downstream target NQO1 in the prostate. A global gene expression analysis comparing the TRAMP and non-transgenic mice revealed dramatic difference in the prostate, including genes encoding phase II detoxification enzymes and cell cycle controlling proteins. Short-term treatment of γTmT could partly prevent the alteration of genes identified in the prostate of TRAMP mice. Furthermore, we found that a mixture of tocotrienols, a less-recognized subclass of vitamin E, suppressed xenografted VCaP prostate tumor in nude mice in part by modulating cell cycle progression.
Subject
(authority = RUETD)
Topic
Pharmaceutical Science
Subject
(authority = ETD-LCSH)
Topic
Phytochemicals--Therapeutic use
Subject
(authority = ETD-LCSH)
Topic
Prostate--Cancer--Treatment
Subject
(authority = ETD-LCSH)
Topic
Cancer--Prevention
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
Identifier
ETD_6151
PhysicalDescription
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electronic resource
InternetMediaType
application/pdf
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text/xml
Extent
1 online resource (xiii, 121 p. : ill.)
Note
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Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Ying Huang
RelatedItem
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TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
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rucore19991600001
Location
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NjNbRU
Identifier
(type = doi)
doi:10.7282/T3SQ922M
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
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The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Huang
GivenName
Ying
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(point = start)
2015-01-05 12:12:57
AssociatedEntity
Name
Ying Huang
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime
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(qualifier = exact);
(point = start)
2015-01-31
DateTime
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2017-01-30
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after January 30th, 2017.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
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ContentModel
ETD
OperatingSystem
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windows xp
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