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Parametric analysis of continuous high shear wet granulation

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TitleInfo
Title
Parametric analysis of continuous high shear wet granulation
Name (type = personal)
NamePart (type = family)
Meng
NamePart (type = given)
Wei
NamePart (type = date)
1988-
DisplayForm
Wei Meng
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Muzzio
NamePart (type = given)
Fernando J
DisplayForm
Fernando J Muzzio
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Ramachandran
NamePart (type = given)
Rohit
DisplayForm
Rohit Ramachandran
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
LIU
NamePart (type = given)
XUE
DisplayForm
XUE LIU
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (encoding = w3cdtf); (qualifier = exact)
2015
DateOther (qualifier = exact); (type = degree)
2015-01
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2015
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
The main focus of this research is to investigate the continuous high shear wet granulation process. Wet granulation is used broadly in the pharmaceutical industry. This technology has many advantages such as enhancing compression and powder handling, decreasing ingredient segregation and ensuring the content uniformity through binding of ingredients to each other. A high level of interest exists at the present time in the continuous version of this technology, both by the US FDA, and by large pharmaceutical manufacturers. Continuous manufacturing methods can provide significant technical and business advantages relative to batch methods. As has been demonstrated in other process industries, continuous manufacturing methods are more robust and controllable. They achieve the same production rates as batch processes in much smaller and thus less capital-intensive equipment. However, despite these advantages, the pharmaceutical industry still relies almost exclusively on traditional batch methods to produce tablets and capsules. In recent years, different continuous WG techniques have been investigated, such as fluid bed agglomeration and twin-screw extrusion. However, integration of these unit operations into a complete continuous tablet manufacturing line is still a bottleneck due to high production cost and poor understanding of impact of granule properties. In this work, a continuous high-shear wet granulation process is examined based on a placebo formulation comprising of 70% ∂-lactose monohydrate and 30% microcrystalline cellulose (Avicel PH101). The process includes two stages. As the powders are fed into the granulator, the blades mounted on the shaft will push the dry powders forward and promote both dispersive axial mixing and convective cross-sectional mixing. This is the mixing stage. The granulation stage occurs once the mixtures reach the nozzle location where a binding liquid (water) is fed via a pump. Then the granule size grows and decays due to nucleation, coalescence, consolidation and attrition or breakage. In this study, two process variables (rotation speed, L/S ratio) and two design parameters (blade configuration and nozzle position) are selected for the I-optimal design. The collected granules are dried in a hot-air convection oven to a desirable LOD (~ 3%). Granule properties, such as particle size distribution, flow properties, density, compaction and are measured. Batches with desirable particle size distribution are selected for further characterization. The rotation speed and L/S ratio have the most significant effects on the granule properties. The optimum operations of this granulation are 0.3 L/S ratio with the rotation speed of 275RPM or 660RPM.
Subject (authority = RUETD)
Topic
Chemical and Biochemical Engineering
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_6037
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (x, 75 p. : ill.)
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Subject (authority = ETD-LCSH)
Topic
Granular materials
Subject (authority = ETD-LCSH)
Topic
Wetting
Subject (authority = ETD-LCSH)
Topic
Drugs--Granulation
Note (type = statement of responsibility)
by Wei Meng
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3RN39KZ
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Meng
GivenName
Wei
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2014-12-02 23:36:00
AssociatedEntity
Name
Wei Meng
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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