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Medicinal plants with antioxidant and antiinflammatory properties in cancer prevention
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Paredes Gonzalez, Ximena Alejandra. Medicinal plants with antioxidant and antiinflammatory properties in cancer prevention. Retrieved from https://doi.org/doi:10.7282/T38G8NF4

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TitleMedicinal plants with antioxidant and antiinflammatory properties in cancer prevention
NameParedes Gonzalez, Ximena Alejandra (author); Kong, Ah-Ng Tony (chair); Suh, Nanjoo (internal member); Kagan, Leonid (internal member); Cai, Li (outside member); Rutgers University; Graduate School - New Brunswick
Date Created2015
Other Date2015-01 (degree)
SubjectPharmaceutical Science, Cancer--Chemoprevention, Medicinal plants, Cancer--Prevention
Extent1 online resource (xxi, 198 p. : ill.)
DescriptionPlants extracts have been used in the folk medicine for hundreds of years because it is believed that they constitute a natural approach in dealing with many diseases including cancer. To detect, prevent and treat cancer before it arises is a great promise in personalized medicine and chemopreventive compounds that have the ability to suppress or block tumor progression are an important approach that has gained increasing attention due their low side effects. Many of these plants and their bioactive compounds have the ability to modulate reactive oxidative species, inflammation, apoptosis mediators and Nrf2/ARE signaling pathway. In this dissertation, we have explored the effect of glucosinolates and the main bioactive compounds of Radix Angelicae Sinensis and Matricaria recutita L. in order to have a better understating on how they are able to activate Nrf2 signaling and the role that they play in Nrf2 interaction with anti-inflammatory, pro-apoptosis and epigenetic signals. We have also discussed the emerging field of cancer and obesity on that crosstalking of these pathways play a pivotal role worsening cancer outcomes representing an emergent and challenging field for prevention and treatment that needs to be further addressed in the future.
NotePh.D.
NoteIncludes bibliographical references
Noteby Ximena Alejandra Paredes Gonzalez
Genretheses, ETD doctoral
Persistent URLhttps://doi.org/doi:10.7282/T38G8NF4
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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