Plants extracts have been used in the folk medicine for hundreds of years because it is believed that they constitute a natural approach in dealing with many diseases including cancer. To detect, prevent and treat cancer before it arises is a great promise in personalized medicine and chemopreventive compounds that have the ability to suppress or block tumor progression are an important approach that has gained increasing attention due their low side effects. Many of these plants and their bioactive compounds have the ability to modulate reactive oxidative species, inflammation, apoptosis mediators and Nrf2/ARE signaling pathway. In this dissertation, we have explored the effect of glucosinolates and the main bioactive compounds of Radix Angelicae Sinensis and Matricaria recutita L. in order to have a better understating on how they are able to activate Nrf2 signaling and the role that they play in Nrf2 interaction with anti-inflammatory, pro-apoptosis and epigenetic signals. We have also discussed the emerging field of cancer and obesity on that crosstalking of these pathways play a pivotal role worsening cancer outcomes representing an emergent and challenging field for prevention and treatment that needs to be further addressed in the future.
Subject (authority = RUETD)
Topic
Pharmaceutical Science
Subject (authority = ETD-LCSH)
Topic
Cancer--Chemoprevention
Subject (authority = ETD-LCSH)
Topic
Medicinal plants
Subject (authority = ETD-LCSH)
Topic
Cancer--Prevention
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_6128
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xxi, 198 p. : ill.)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Ximena Alejandra Paredes Gonzalez
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
Rutgers University. Graduate School - New Brunswick
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Type
License
Name
Author Agreement License
Detail
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