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Regulation of mouse behavior by ephrin-a5

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TitleInfo
Title
Regulation of mouse behavior by ephrin-a5
Name (type = personal)
NamePart (type = family)
Sheleg
NamePart (type = given)
Michal
NamePart (type = date)
1983-
DisplayForm
Michal Sheleg
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Zhou
NamePart (type = given)
Renping
DisplayForm
Renping Zhou
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Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Chen
NamePart (type = given)
Suzie
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Suzie Chen
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Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Wagner
NamePart (type = given)
George C
DisplayForm
George C Wagner
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Richardson
NamePart (type = given)
Jason R
DisplayForm
Jason R Richardson
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Shumyatsky
NamePart (type = given)
Gleb
DisplayForm
Gleb Shumyatsky
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (encoding = w3cdtf); (qualifier = exact)
2015
DateOther (qualifier = exact); (type = degree)
2015-01
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2015
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Social behaviors in mammals are regulated by core neural circuits that respond to stimuli from the environment. These circuits are formed by guidance molecules and create a “map” in the brain that corresponds to sensory surface and motor effectors. Among these guidance molecules are the Eph/ ephrin family of receptor tyrosine kinases. In this study we examined the role of ephrin-A5, a ligand for the Eph receptors, in animal behavior. We found that ephrin-A5 inactivation in the mouse caused delays in the maturation of sensorimotor skills during development and defective behaviors in adult life. Specifically, ephrin-A5-/- mothers are impaired in maternal behavior in the form of nest building and pup retrieval and male null mice show severe reduction in inter-male aggression. In addition, anxiety-like behavior is reduced in both male and female null mice. An examination of the general olfactory function revealed no apparent deficit; ephrin-A5-/- mice were able to use their sense of smell to locate a flavored cereal that was buried beneath the cage bedding, they showed increased investigatory sniffs in response to new odor, and they were able to discriminate between male and female mice, suggesting that neuronal circuits that control foraging and sex discrimination are intact. However stimuli that control maternal care, inter-male aggression and anxiety may not be directed to the appropriate circuits in the null brain. We further examined molecules that have been shown to act in theses circuits such as testosterone, corticosterone, serotonin and arginine vasopressin (AVP) and found alteration in the expression of AVP in the null brain. Taken together, our studies revealed a novel role for ephrin-A5 in the development of appropriate behaviors.
Subject (authority = RUETD)
Topic
Toxicology
Subject (authority = ETD-LCSH)
Topic
Receptor-ligand complexes
Subject (authority = ETD-LCSH)
Topic
Protein-tyrosine kinase
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_6014
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xii, 128 p. : ill.)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Michal Sheleg
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3JS9S55
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Sheleg
GivenName
Michal
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2014-10-30 16:30:48
AssociatedEntity
Name
michal Sheleg
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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