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Analyzing the mixing dynamics of a tumbling bin blender using discrete element modeling
Descriptive
TitleInfo
Title
Analyzing the mixing dynamics of a tumbling bin blender using discrete element modeling
Name
(type = personal)
NamePart
(type = family)
Karkala
NamePart
(type = given)
Subhodh Kumar
NamePart
(type = date)
1984-
DisplayForm
Subhodh Kumar Karkala
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Ramachandran
NamePart
(type = given)
Rohit
DisplayForm
Rohit Ramachandran
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Ierapetritou
NamePart
(type = given)
Marianthi G.
DisplayForm
Marianthi G. Ierapetritou
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Glasser
NamePart
(type = given)
Benjamin J.
DisplayForm
Benjamin J. Glasser
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
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NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2015
DateOther
(qualifier = exact);
(type = degree)
2015-05
CopyrightDate
(encoding = w3cdtf);
(qualifier = exact)
2015
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Powder mixing is a critical step in pharmaceutical processes as it determines the final tablet composition. In this study a discrete element model (DEM) has been developed for an industrial scale tumbling bin blender in which three different materials are blended together. The dynamics of the mixing have been evaluated with the analysis of critical quality attributes (CQAs) such as relative standard deviation (RSD) and segregation intensity. This model has been developed and calibrated using an experimental setup in which the blend composition is monitored through a near-infrared range (NIR) probe mounted on the blender lid. The final blend quality is judged on the basis of measurements only at the lid in the experimental setup. However, the model has been used to study the quality of mixing in different locations inside the blender. The model is able identify poorly mixed zones and can be used to investigate other potential locations for the NIR probe. The effect of key process parameters (i.e. blender RPM and loading order of materials) on the quality of mixing has also been studied.
Subject
(authority = RUETD)
Topic
Chemical and Biochemical Engineering
Subject
(authority = ETD-LCSH)
Topic
Granular materials--Mathematical models
Subject
(authority = ETD-LCSH)
Topic
Finite element method
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_6337
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (vii, 37 p. : ill.)
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Subhodh Kumar Karkala
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Location
PhysicalLocation
(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3KD20SK
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Karkala
GivenName
Subhodh
MiddleName
Kumar
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2015-04-13 16:53:29
AssociatedEntity
Name
Subhodh Karkala
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
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ContentModel
ETD
OperatingSystem
(VERSION = 5.1)
windows xp
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