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Process systems engineering methods for the development of continuous pharmaceutical manufacturing processes
Descriptive
TitleInfo
Title
Process systems engineering methods for the development of continuous pharmaceutical manufacturing processes
Name
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NamePart
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Rogers
NamePart
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Amanda
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Amanda Rogers
Role
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author
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NamePart
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Ierapetritou
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Marianthi G
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Marianthi G Ierapetritou
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Advisory Committee
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chair
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Muzzio
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Fernando
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Fernando Muzzio
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Advisory Committee
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internal member
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NamePart
(type = family)
Ramachandran
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Rohit
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Rohit Ramachandran
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Advisory Committee
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internal member
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Tabora
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Jose
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Jose Tabora
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Advisory Committee
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outside member
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Rutgers University
Role
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degree grantor
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Graduate School - New Brunswick
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Text
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theses
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2015
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2015-05
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2015
Place
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xx
Language
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eng
Abstract
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The objective of this dissertation is to develop mathematical methods to assist in the development of continuous processes for the manufacture of pharmaceutical drug products. Specifically, modeling, analysis and optimization techniques will be developed in order to apply concepts from the field of process systems engineering to pharmaceutical development. These concepts, including sensitivity analysis, feasibility and flexibility analysis and optimal design under uncertainty, can contribute to the development of robust and well-understood manufacturing processes. This is consistent with the aim Quality-by-Design in the pharmaceutical process development. Throughout this dissertation, case studies related to continuous solids-based manufacturing will be used to demonstrate the role that process systems engineering can play in process development. The mathematical methods introduced in this dissertation will emphasize the use of reduced-order and surrogate models to address the unique challenges associated with modeling, analysis and optimization of solids-based processes.
Subject
(authority = RUETD)
Topic
Chemical and Biochemical Engineering
Subject
(authority = ETD-LCSH)
Topic
Pharmaceutical industry--Quality control
Subject
(authority = ETD-LCSH)
Topic
Manufacturing processes
Subject
(authority = ETD-LCSH)
Topic
Pharmaceutical chemistry
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Rutgers University Electronic Theses and Dissertations
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ETD_6197
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electronic resource
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application/pdf
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Extent
1 online resource (xii, 170 p. : ill.)
Note
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Ph.D.
Note
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Includes bibliographical references
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by Amanda Rogers
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Title
Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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NjNbRU
Identifier
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doi:10.7282/T37H1MGJ
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
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The author owns the copyright to this work.
RightsHolder
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Name
FamilyName
Rogers
GivenName
Amanda
Role
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Permission or license
DateTime
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2015-02-27 16:24:39
AssociatedEntity
Name
Amanda Rogers
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
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ETD
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windows xp
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