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Hepatic triglyceride metabolism in response to acute and chronic exercise
Descriptive
TitleInfo
Title
Hepatic triglyceride metabolism in response to acute and chronic exercise
SubTitle
a tale of two intensities
Name
(type = personal)
NamePart
(type = family)
Tuazon
NamePart
(type = given)
Marc A.
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Marc A. Tuazon
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Campbell
NamePart
(type = given)
Sara C
DisplayForm
Sara C Campbell
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Anthony
NamePart
(type = given)
Tracy G
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Tracy G Anthony
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Arent
NamePart
(type = given)
Shawn M
DisplayForm
Shawn M Arent
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Brasaemle
NamePart
(type = given)
Dawn L
DisplayForm
Dawn L Brasaemle
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
McKeever
NamePart
(type = given)
Kenneth H
DisplayForm
Kenneth H McKeever
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2015
DateOther
(qualifier = exact);
(type = degree)
2015-05
CopyrightDate
(encoding = w3cdtf);
(qualifier = exact)
2015
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Impaired hepatic triglyceride (TG) metabolism is associated with dysfunctions such as insulin resistance and elevated VLDL-TG secretion. Chronic exercise lowers plasma TG and hepatic TG, however, many benefits of chronic exercise are due to repeated effects of single exercise sessions. Little is known, however, about effects of acute exercise on hepatic TG metabolism or the influence of exercise intensity in males vs. females. We examined impacts of single bouts of moderate-intensity continuous exercise (CE) vs. high-intensity interval exercise (HIIE) on hepatic TG metabolism and secretion in mice of both sexes. Hepatic TG was transiently increased on the day of exercise and in females the increase was greater with HIIE. These exercise-related changes appeared driven by enhanced transcription of the lipid-droplet coating protein Perilipin 2. On the day after exercise, VLDL-TG secretion rate was only reduced by HIIE in females. These findings demonstrated intensity-dependent and sex-specific effects of acute exercise. Because of our findings that single bouts of HIIE alter hepatic TG metabolism more than CE and the potential for chronic exercise to attenuate severity of complications associated with menopause, we compared 6 weeks of training using these exercise types on hepatic TG metabolism and secretion, glucose tolerance, body composition, and strength in ovariectomized (OVX) and sham-operated (SHAM) mice. Additionally, we measured energy expenditure and substrate oxidation during and immediately after exercise and assessed post-exercise spontaneous physical activity (SPA) to further characterize these exercise modalities. In OVX and SHAM, CE and HIIE elicited similar energy expenditures during exercise and in the post-exercise period lowered absolute carbohydrate oxidation and SPA. OVX vs. SHAM displayed impaired glucose tolerance, elevated blood glucose, and greater body fat despite lower hepatic TG, as well as lower strength, and these outcomes were not affected by training. In contrast to responses to single exercise sessions, chronic HIIE increased hepatic AMPK protein. Further, the reduction in VLDL-TG secretion after a single HIIE session was not maintained after training. These results reveal intensity-dependent effects of habitual exercise on hepatic AMPK expression and with our findings of single bouts reveal distinct responses in hepatic TG metabolism to acute vs. chronic exercise.
Subject
(authority = RUETD)
Topic
Nutritional Sciences
Subject
(authority = ETD-LCSH)
Topic
Triglycerides--Metabolism
Subject
(authority = ETD-LCSH)
Topic
Exercise
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_6299
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xii, 127 p. : ill.)
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Marc A. Tuazon
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Location
PhysicalLocation
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3RB76GS
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Tuazon
GivenName
Marc
MiddleName
A.
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2015-04-10 16:22:14
AssociatedEntity
Name
Marc Tuazon
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2015-05-31
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = end)
2017-05-30
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after May 30th, 2017.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
(ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem
(VERSION = 5.1)
windows xp
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