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The association of p75NTR and co-receptors in hippocampal neurons and astrocytes
Descriptive
TitleInfo
Title
The association of p75NTR and co-receptors in hippocampal neurons and astrocytes
Name
(type = personal)
NamePart
(type = family)
Yarotsky
NamePart
(type = given)
John J.
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John J. Yarotsky
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author
Name
(type = personal)
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Bonder
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(type = given)
Edward
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Edward Bonder
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Advisory Committee
Role
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chair
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NamePart
(type = family)
Altan-Boonet
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Nihal
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Nihal Altan-Boonet
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Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Kim
NamePart
(type = given)
Heasun
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Heasun Kim
Affiliation
Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Dreyfus
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(type = given)
Cheryl
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Cheryl Dreyfus
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Advisory Committee
Role
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outside member
Name
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NamePart
Rutgers University
Role
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(authority = RULIB)
degree grantor
Name
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NamePart
Graduate School - Newark
Role
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school
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Text
Genre
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theses
OriginInfo
DateCreated
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2015
DateOther
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(type = degree)
2015-05
CopyrightDate
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(qualifier = exact)
2015
Place
PlaceTerm
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xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Neurons in the hippocampus are dependent on neurotrophins for survival. Upon injury, proneurotrophins cause hippocampal neurons to undergo apoptosis. These two distinct effects can be mediated by the interaction of p75NTR with different co-receptors. Trk receptors typically signal for survival and the signaling is enhanced in the presence of p75NTR. Apoptotic signaling through proneurotrophins is dependent on the presence of p75NTR and sortilin. The work in this thesis demonstrates that the association of p75NTR and TrkB, and the association of p75NTR with sortilin are both ligand dependent. The association of p75NTR and TrkB is dependent on internalization of the complex and TrkB activation . Sortilin and p75NTR associated both on the cell surface and in intracellular vesicles. Hippocampal astrocytes also express these receptors but do not signal for death upon proneurotophin treatment and are not dependent on mature neurotrophins for survival. This thesis demonstrates that the interaction of p75NTR and sortilin does not occur on hippocampal astrocytes. TrkB and p75NTR present on hippocampal astrocytes do not increase their association following treatment with BDNF. Taken together, the different responses between hippocampal neurons and astrocytes may be partially determined by limiting the interactions of p75NTR and co- receptors on astocytes. The data in this thesis demonstrate that the association of p75 with different co- receptors may determine the trafficking of these receptors through intracellular compartments, which is likely to influence intracellular signaling and the functional response of neurons and astrocytes to these factors.
Subject
(authority = RUETD)
Topic
Biology
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
Identifier
ETD_6490
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electronic resource
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application/pdf
InternetMediaType
text/xml
Extent
1 online resource (viii, 90 p. : ill.)
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Subject
(authority = ETD-LCSH)
Topic
Hippocampus (Brain)
Subject
(authority = ETD-LCSH)
Topic
Astrocytes
Note
(type = statement of responsibility)
by John J. Yarotsky
RelatedItem
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TitleInfo
Title
Graduate School - Newark Electronic Theses and Dissertations
Identifier
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rucore10002600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3QR501J
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
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The author owns the copyright to this work.
RightsHolder
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Name
FamilyName
Yarotsky
GivenName
John
Role
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RightsEvent
Type
Permission or license
DateTime
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(qualifier = exact);
(point = start)
2015-04-30 15:04:30
AssociatedEntity
Name
John Yarotsky
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - Newark
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
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ETD
OperatingSystem
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windows xp
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