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Evaluation of a camptothecin/sodium-R-alpha lipoate combination for the treatment of non-small cell lung cancer

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TitleInfo
Title
Evaluation of a camptothecin/sodium-R-alpha lipoate combination for the treatment of non-small cell lung cancer
Name (type = personal)
NamePart (type = family)
Ibrahim
NamePart (type = given)
Sherif
NamePart (type = date)
1981-
DisplayForm
Sherif Ibrahim
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Sinko
NamePart (type = given)
Patrick
DisplayForm
Patrick Sinko
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Colaizzi
NamePart (type = given)
John L.
DisplayForm
John L. Colaizzi
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Suh
NamePart (type = given)
Nanjoo
DisplayForm
Nanjoo Suh
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Prud'homme
NamePart (type = given)
Robert
DisplayForm
Robert Prud'homme
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2015
DateOther (qualifier = exact); (type = degree)
2015-01
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2015
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Lung cancer is the most common cause of cancer-related mortality among both men and women in the United States and worldwide, killing more people than breast, prostate, and colon cancers combined. It is estimated that 1.37 million people worldwide die of the disease annually. Non-small cell lung cancer (NSCLC) accounts for the majority of lung cancer cases worldwide and thus remains a primary focus of therapeutic lung cancer research. Currently used treatments for NSCLC include surgery, chemotherapy, radiotherapy, and targeted/biological therapy. Despite these treatment options, the disease remains a considerable cause of morbidity and mortality. Thus, more effective treatment options are highly sought after. NSCLC is most often diagnosed at late stages, at which time surgery can no longer offer a curative outcome. Thus, cytotoxic chemotherapy remains the first-line treatment for late-stage NSCLC. However, efficacy has been modest at best and toxicity remains a significant drawback. Improvements to current chemotherapeutic strategies are direly needed. The objective of this thesis is to evaluate a combination of camptothecin (CPT) and sodium-R-alpha lipoate (Na-RALA) for the treatment of NSCLC. Using a variety of concentration- and time-dependent in vitro assays, we found that a combination of CPT and Na-RALA: 1) exerted additive/synergistic cytotoxic effects against A549 human NSCLC adenocarcinoma cells; 2) has higher efficacy, higher cancer-selectivity, and lower toxicity towards normal cells than CPT alone; 3) simultaneously targets multiple hallmarks of cancer, including migration, invasion, senescence, and angiogenesis, and thus has the potential to reduce metastasis and general progression of NSCLC. In vivo evaluation of the combination began with the development of an orthotopic xenograft NSCLC model. The intrathoracic (IT) and intracardiac (IC) mouse models of NSCLC were deemed most fitting for our study design and objectives. A combination of CPT and Na-RALA deserves further evaluation as a treatment for NSCLC.
Subject (authority = RUETD)
Topic
Pharmaceutical Science
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_6078
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (x, 111 p. : ill.)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Subject (authority = ETD-LCSH)
Topic
Lungs--Cancer--Treatment
Subject (authority = ETD-LCSH)
Topic
Camptothecin
Note (type = statement of responsibility)
by Sherif Ibrahim
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T35T3NCV
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Ibrahim
GivenName
Sherif
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2014-12-17 12:14:43
AssociatedEntity
Name
Sherif Ibrahim
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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