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Targeting tumor metastases: drug delivery mechanisms and technologies

Descriptive

TypeOfResource
Text
TitleInfo
Title
Targeting tumor metastases: drug delivery mechanisms and technologies
Name (type = personal)
NamePart (type = family)
Ganapathy
NamePart (type = given)
Vidya
Affiliation
Biomedical Engineering, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Moghe
NamePart (type = given)
Prabhas V.
Affiliation
Biomedical Engineering, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (type = personal); (valueURI = http://orcid.org/0000-0002-4924-0721)
NamePart (type = family)
Roth
NamePart (type = given)
Charles M.
Affiliation
Chemical & Biochemical Engineering, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Chemical & Biochemical Engineering
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Biomedical Engineering
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
School of Engineering
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Accepted Manuscript (AM)
Note (type = peerReview)
Peer reviewed
OriginInfo
Publisher
Elsevier
DateIssued (encoding = w3cdtf); (keyDate = yes); (qualifier = exact)
2015
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
44 p.
Extension
DescriptiveEvent
Type
Citation
AssociatedObject
Name
Journal of Controlled Release
Type
Journal
Relationship
Has part
Identifier (type = volume and issue)
219
Reference (type = url)
http://dx.doi.org/10.1016/j.jconrel.2015.09.042
Detail
215-223
DateTime (encoding = w3cdtf)
2015
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Institutes of Health (U.S.)
AssociatedEntity
Role
Originator
Name
Moghe, Prabhas V.
AssociatedEntity
Role
Originator
Name
Roth, Charles M.
AssociatedEntity
Role
Originator
Name
Riman, Richard
AssociatedObject
Type
Grant number
Name
1R01 EB018378-02
Subject (authority = local)
Topic
Cancer stem cell
Subject (authority = local)
Topic
Intravasation
Subject (authority = local)
Topic
Extravasation
Subject (authority = local)
Topic
Metastasis
Subject (authority = local)
Topic
Targeted delivery
Abstract (type = abstract)
Primary sites of tumor are the focal triggers of cancers, yet it is the subsequent metastasis events that cause the majority of the morbidity and mortality. Metastatic tumor cells exhibit a phenotype that differs from that of the parent cells, as they represent a resistant, invasive subpopulation of the original tumor, may have acquired additional genetic or epigenetic alterations under exposure to prior chemotherapeutic or radiotherapeutic treatments, and reside in a microenvironment differing from that of its origin. This combination of resistant phenotype and distal location make tracking and treating metastases particularly challenging. In this review, we highlight some of the unique biological traits of metastasis, which in turn, inspire emerging strategies for targeted imaging of metastasized tumors and metastasis-directed delivery of therapeutics.
RelatedItem (type = host)
TitleInfo
Title
Ganapathy, Vidya
Identifier (type = local)
rucore30172000001
RelatedItem (type = host)
TitleInfo
Title
Moghe, Prabhas V.
Identifier (type = local)
rucore30172100001
RelatedItem (type = host)
TitleInfo
Title
Roth, Charles M.
Identifier (type = local)
rucore30171900001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3DJ5HH5
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Rights

RightsDeclaration (AUTHORITY = FS); (ID = rulibRdec0004)
Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers.Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work.I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others.I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work.By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Submission agreement v. 1
Detail
I am submitting my own manuscript:Grant Compliance - I am submitting an electronic version of my final manuscript that is the result of research supported, in whole or in part, with direct costs by the National Institutes of Health. This submission is voluntary and fulfills the existing requirement to provide publications as part of NIH project progress reports. Public Release - I permit public release of this manuscript via PubMed Central available after any applicable embargo period prescribed by the journal in which it appeared. Copyright Compliance - This public release permission is consistent with any copyright agreement about this manuscript that I have made with the journal publisher.
RightsEvent
Type
Embargo
DateTime (encoding = w3cdtf); (point = end); (qualifier = exact); (keyDate = no)
2016-10-15
DateTime (encoding = w3cdtf); (point = start); (qualifier = exact); (keyDate = no)
2015-10-15
Detail
Access to this PDF has been restricted at the publisher's request. It will be publicly available after: 2016-10-15.
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
Document
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