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Remodeling sensory cortical maps implants specific behavioral memory

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TypeOfResource
Text
TitleInfo
Title
Remodeling sensory cortical maps implants specific behavioral memory
Name (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (type = personal); (valueURI = http://orcid.org/0000-0002-3633-5422)
NamePart (type = family)
Bieszczad
NamePart (type = given)
Kasia M.
Affiliation
Psychology (New Brunswick), Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Miasnikov
NamePart (type = given)
Alexandre A.
Affiliation
University of California, Irvine
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Weinberger
NamePart (type = given)
Norman M.
Affiliation
University of California, Irvine
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Psychology (New Brunswick)
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
School of Arts and Sciences (SAS) (New Brunswick)
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Accepted Manuscript (AM)
Genre (authority = ExL-Esploro)
Accepted Manuscript
Note (type = peerReview)
Peer reviewed
Note (type = special display note)
Author's Manuscript is also available open access in PubMed Central: http://www.ncbi.nlm.nih.gov/pubmed/23639876.
OriginInfo
DateIssued (encoding = w3cdtf); (keyDate = yes)
2013
Abstract (type = Abstract)
Neural mechanisms underlying the capacity of memory to be rich in sensory detail are largely unknown. A candidate mechanism is learning-induced plasticity that remodels the adult sensory cortex. Here, expansion in the primary auditory cortical (A1) tonotopic map of rats was induced by pairing a 3.66-kHz tone with activation of the nucleus basalis, mimicking the effects of natural associative learning. Remodeling of A1 produced de novo specific behavioral memory, but neither memory nor plasticity was consistently at the frequency of the paired tone, which typically decreased in A1 representation. Rather, there was a specific match between individual subjects' area of expansion and the tone that was strongest in each animal's memory, as determined by post-training frequency generalization gradients. These findings provide the first demonstration of a match between the artificial induction of specific neural representational plasticity and artificial induction of behavioral memory. As such, together with prior and present findings for detection, correlation and mimicry of plasticity with the acquisition of memory, they satisfy a key criterion for neural substrates of memory. This demonstrates that directly remodeling sensory cortical maps is sufficient for the specificity of memory formation.
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
21 p.
Extension
DescriptiveEvent
Type
Citation
AssociatedObject
Name
Neuroscience
Type
Journal
Relationship
Has part
Reference (type = url)
http://dx.doi.org/10.1016/j.neuroscience.2013.04.038
Identifier (type = volume and issue)
246
Detail
40-51
DateTime (encoding = w3cdtf)
2013
Identifier (type = PMCID)
PMC3691301
Identifier (type = doi)
doi:10.7282/T3J1052C
Subject (authority = local)
Topic
Acetylcholine
Subject (authority = local)
Topic
Auditory cortex
Subject (authority = local)
Topic
Brain stimulation
Subject (authority = local)
Topic
Neurophysiology
Subject (authority = local)
Topic
Nucleus basalis
RelatedItem (type = host)
TitleInfo
Title
Bieszczad, Kasia M.
Identifier (type = local)
rucore30174100001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
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RightsDeclaration (AUTHORITY = FS); (ID = rulibRdec0004)
Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Sole author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers. Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work.I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others.I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work.By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
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RULTechMD (ID = TECHNICAL1)
ContentModel
Document
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