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Nicotinic acetylcholine receptors in rat forebrain that bind ¹⁸F-nifene: relating PET imaging, autoradiography, and behavior

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TitleInfo
Title
Nicotinic acetylcholine receptors in rat forebrain that bind ¹⁸F-nifene: relating PET imaging, autoradiography, and behavior
Name (type = personal); (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (valueURI = http://orcid.org/0000-0002-3633-5422)
NamePart (type = family)
Bieszczad
NamePart (type = given)
Kasia M.
Affiliation
Psychology (New Brunswick), Rutgers University
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Kant
NamePart (type = given)
Ritu
Role
RoleTerm (type = text); (authority = marcrt)
author
Affiliation
University of California, Irvine
Name (type = personal)
NamePart (type = family)
Constantinescu
NamePart (type = given)
Cristian C.
Affiliation
University of California, Irvine
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Pandey
NamePart (type = given)
Suresh K.
Affiliation
University of California, Irvine
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Kawai
NamePart (type = given)
Hideki D.
Affiliation
University of California, Irvine
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Metherate
NamePart (type = given)
Raju
Affiliation
University of California, Irvine
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Weinberger
NamePart (type = given)
Norman M.
Affiliation
University of California, Irvine
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Mukherjee
NamePart (type = given)
Jogeshwar
Affiliation
University of California, Irvine
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = corporate); (authority = RutgersOrg-Department)
NamePart
Psychology (New Brunswick)
Name (type = corporate); (authority = RutgersOrg-School)
NamePart
School of Arts and Sciences (SAS) (New Brunswick)
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Accepted Manuscript (AM)
Note (type = peerReview)
Peer reviewed
Note (type = special display note)
Author's Manuscript is also available open access in PubMed Central: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292694.
Note (type = version identification)
This is the peer reviewed version of the following article: Bieszczad, K. M., Kant, R., Constantinescu, C. C., Pandey, S. K., Kawai, H. D., Metherate, R., Weinberger, N. M. and Mukherjee, J. (2012), Nicotinic acetylcholine receptors in rat forebrain that bind 18F-nifene: Relating PET imaging, autoradiography, and behavior. Synapse, 66: 418–434. doi: 10.1002/syn.21530, which has been published in final form at http://dx.doi.org/10.1002/syn.21530. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
OriginInfo
DateIssued (encoding = w3cdtf); (keyDate = yes)
2012
Abstract (type = Abstract)
Nicotinic acetylcholine receptors (nAChRs) in the brain are important for cognitive function; however, their specific role in relevant brain regions remains unclear. In this study, we used the novel compound ¹⁸F-nifene to examine the distribution of nAChRs in the rat forebrain, and for individual animals related the results to behavioral performance on an auditory-cognitive task. We first show negligible binding of ¹⁸F-nifene in mice lacking the β2 nAChR subunit, consistent with previous findings that ¹⁸F-nifene binds to α4β2* nAChRs. We then examined the distribution of ¹⁸F-nifene in rat using three methods: in vivo PET, ex vivo PET and autoradiography. Generally, ¹⁸F-nifene labeled forebrain regions known to contain nAChRs, and the three methods produced similar relative binding among regions. Importantly, ¹⁸F-nifene also labeled some white matter (myelinated axon) tracts, most prominently in the temporal subcortical region that contains the auditory thalamocortical pathway. Finally, we related ¹⁸F-nifene binding in several forebrain regions to each animal's performance on an auditory-cued, active avoidance task. The strongest correlations with performance after 14 days training were found for ¹⁸F-nifene binding in the temporal subcortical white matter, subiculum, and medial frontal cortex (correlation coefficients, r > 0.8); there was no correlation with binding in the auditory thalamus or auditory cortex. These findings suggest that individual performance is linked to nicotinic functions in specific brain regions, and further support a role for nAChRs in sensory-cognitive function.
Language
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English
PhysicalDescription
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application/pdf
Extent
26 p.
Extension
DescriptiveEvent
Type
Citation
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Name
Synapse
Type
Journal
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Has part
Identifier (type = volume and issue)
66(5)
Reference (type = url)
http://dx.doi.org/10.1002/syn.21530
Detail
418-434
DateTime (encoding = w3cdtf)
2012
Extension
DescriptiveEvent
Type
Grant award
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Role
Funder
Name
National Institutes of Health (U.S.)
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Originator
Name
Mukherjee, Jogeshwar
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Type
Grant number
Name
R01AG029479
Extension
DescriptiveEvent
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Grant award
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Role
Funder
Name
National Institutes of Health (U.S.)
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Originator
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Weinberger, Norman M.
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Detail
R01DC02938
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National Institutes of Health (U.S.)
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Weinberger, Norman M.
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Type
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R01DC010013
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DescriptiveEvent
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Funder
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National Institutes of Health (U.S.)
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Originator
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Bieszczad, Kasia M.
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Name
DC009163
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Grant award
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Funder
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National Institutes of Health (U.S.)
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Originator
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Kawai, Hideki D.
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RO3DC08204
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Funder
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National Institutes of Health (U.S.)
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Originator
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Metherate, Raju
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R01DA12929
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Grant award
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Funder
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National Institutes of Health (U.S.)
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Role
Originator
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Metherate, Raju
AssociatedObject
Type
Grant number
Name
P30DC08369
Identifier (type = PMCID)
PMC3292694
Subject (authority = local)
Topic
Nicotine
Subject (authority = local)
Topic
Learning
Subject (authority = local)
Topic
Memory
Subject (authority = local)
Topic
Auditory
Subject (authority = local)
Topic
Thalamocortical
Subject (authority = local)
Topic
Prefrontal
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TitleInfo
Title
Bieszczad, Kasia M.
Identifier (type = local)
rucore30174100001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3C82C7Q
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