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Differential gene regulation of GHSR signaling pathway in the arcuate nucleus and NPY neurons by fasting, diet-induced obesity, and 17β-estradiol

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TypeOfResource
Text
TitleInfo
Title
Differential gene regulation of GHSR signaling pathway in the arcuate nucleus and NPY neurons by fasting, diet-induced obesity, and 17β-estradiol
Name (type = corporate); (authority = RutgersOrg-Department)
NamePart
Animal Sciences
Name (type = corporate); (authority = RutgersOrg-School)
NamePart
School of Environmental and Biological Sciences (SEBS)
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Accepted Manuscript (AM)
Note (type = peerReview)
Peer reviewed
OriginInfo
Publisher
Elsevier
DateIssued (encoding = w3cdtf); (qualifier = exact); (keyDate = yes)
2016
Abstract (type = Abstract)
Ghrelin’s receptor, growth hormone secretagogue receptor (GHSR), is highly expressed in the arcuate nucleus (ARC) and in neuropeptide Y (NPY) neurons. Fasting, diet-induced obesity (DIO), and 17β-estradiol (E2) influence ARC Ghsr expression. It is unknown if these effects occur in NPY neurons. Therefore, we examined the expression of Npy, Agrp, and GHSR signaling pathway genes after fasting, DIO, and E2 replacement in ARC and pools of NPY neurons. In males, fasting increased ARC Ghsr and NPY Foxo1 but decreased NPY Ucp2. In males, DIO decreased ARC and NPY Ghsr and Cpt1c. In fed females, E2 increased Agrp, Ghsr, Cpt1c, and Foxo1 in ARC. In NPY pools, E2 decreased Foxo1 in fed females but increased Foxo1 in fasted females. DIO in females suppressed Agrp and augmented Cpt1c in NPY neurons. In summary, genes involved in GHSR signaling are differentially regulated between the ARC and NPY neurons in a sex-dependent manner.
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
51 p.
Subject (authority = local)
Topic
Arcuate nucleus
Subject (authority = LCSH)
Topic
Ghrelin
Subject (authority = LCSH)
Topic
Neuropeptide Y
Subject (authority = LCSH)
Topic
Fasting
Subject (authority = local)
Topic
Diet-induced obesity
Subject (authority = local)
Topic
17β-estradiol
Extension
DescriptiveEvent
Type
Citation
AssociatedObject
Name
Molecular and Cellular Endocrinology
Type
Journal
Relationship
Has part
Reference (type = url)
https://dx.doi.org/10.1016/j.mce.2015.11.007
Identifier (type = volume and issue)
422,
Detail
42-56
DateTime (encoding = w3cdtf)
2016
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Institutes of Health
AssociatedEntity
Role
Originator
Name
Troy A. Roepke
AssociatedObject
Type
Grant number
Name
R00DK083457
AssociatedObject
Type
Grant number
Name
R00DK083457-S1
Name (type = personal)
NamePart (type = family)
Yasrebi
NamePart (type = given)
Ali
Affiliation
Animal Sciences, Rutgers University
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Hsieh
NamePart (type = given)
Anna
Affiliation
Animal Sciences, Rutgers University
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal); (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (valueURI = http://orcid.org/0000-0002-5489-0198)
NamePart (type = family)
Mamounis
NamePart (type = given)
Kyle
Affiliation
Animal Sciences, Rutgers University
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Krumm
NamePart (type = given)
Elizabeth A.
Affiliation
Animal Sciences, Rutgers University
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Yang
NamePart (type = given)
Jennifer A.
Affiliation
Animal Sciences, Rutgers University
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Magby
NamePart (type = given)
Jason
Affiliation
Animal Sciences, Rutgers University
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Hu
NamePart (type = given)
Pu
Affiliation
Animal Sciences, Rutgers University
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal); (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (valueURI = http://orcid.org/0000-0001-5426-2266)
NamePart (type = family)
Roepke
NamePart (type = given)
Troy A.
Affiliation
Animal Sciences, Rutgers University
Role
RoleTerm (type = text); (authority = marcrt)
author
RelatedItem (type = host)
TitleInfo
Title
Roepke, Troy A.
Identifier (type = local)
rucore30176800001
RelatedItem (type = host)
TitleInfo
Title
Yasrebi, Ali
Identifier (type = local)
rucore30190700001
RelatedItem (type = host)
TitleInfo
Title
Yang, Jennifer A.
Identifier (type = local)
rucore30190600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T38W3G7M
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Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
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Copyright protected
Availability
Status
Open
Reason
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RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers.Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work.I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others.I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work.By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
RightsEvent
Type
Embargo
DateTime (point = start); (encoding = w3cdtf)
2015-12-01
DateTime (point = end); (encoding = w3cdtf)
2017-02-15
Detail
Access to this PDF has been restricted at the publisher's request. The publisher, Elsevier, requires a 12 month embargo from the date the article was published. The article in this repository will be publicly available after February 15, 2017.
RightsEvent
Type
Publication notice
Detail
© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
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ContentModel
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